concept

PI3K/AKT/MTOR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PI3K/AKT/MTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

500Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	PI3K/AKT/MTOR
Key Genes/Proteins	ABCA1, AKT, ALS, AMPK, APOE, ATG5
Related Diseases	ALZHEIMER, ALZHEIMER'S DISEASE, APOPTOSIS
Related Pathways	AUTOPHAGY

Pathway Diagram

graph TD
    PI3K_AKT_MTOR["PI3K/AKT/MTOR"]
    style PI3K_AKT_MTOR fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    PI3K_AKT_MTOR -->|"regulates"| Insulin_Resistance(Insulin Resistance)
    PI3K_AKT_MTOR -->|"involved_in"| Glioblastoma["Glioblastoma"]
    PI3K_AKT_MTOR -->|"regulates"| Cell_Proliferation["Cell Proliferation"]
    PI3K_AKT_MTOR -->|"regulates"| Cell_Survival["Cell Survival"]
    PI3K_AKT_MTOR -->|"activates"| multiple_myeloma["multiple myeloma"]
    PI3K_AKT_MTOR -->|"involved_in"| Hormone_Receptor_Positive_Brea["Hormone Receptor-Positive Breast Cancer"]
    PI3K_AKT_MTOR -->|"involved_in"| Breast_Cancer["Breast Cancer"]
    PI3K_AKT_MTOR -->|"involved_in"| Colorectal_Cancer["Colorectal Cancer"]
    PI3K_AKT_MTOR -->|"activates"| Triple_Negative_Breast_Cancer["Triple-Negative Breast Cancer"]
    Gomisin_N["Gomisin N"] -->|"activates"| PI3K_AKT_MTOR
    Paxalisib{"Paxalisib"} -.->|"inhibits"| PI3K_AKT_MTOR
    Cordycepin["Cordycepin"] -.->|"inhibits"| PI3K_AKT_MTOR
    Capivasertib{"Capivasertib"} -.->|"inhibits"| PI3K_AKT_MTOR
    Alpelisib{"Alpelisib"} -.->|"inhibits"| PI3K_AKT_MTOR
    SYK([SYK]) -->|"regulates"| PI3K_AKT_MTOR
    MTOR([MTOR]) -->|"component_of"| PI3K_AKT_MTOR
    BBR{"BBR"} -.->|"inhibits"| PI3K_AKT_MTOR
    Polygonatum_sibiricum_polysacc["Polygonatum sibiricum polysaccharide"] -->|"activates"| PI3K_AKT_MTOR
    Ly294002{"Ly294002"} -.->|"inhibits"| PI3K_AKT_MTOR

Outgoing (217)

Target	Relation	Type	Str
Glioblastoma	involved_in	disease	0.95
Triple-Negative Breast Cancer	activates	disease	0.95
Glioblastoma	upregulates	disease	0.95
multiple myeloma	activates	disease	0.95
Colorectal Cancer	involved_in	disease	0.95
Hormone Receptor-Positive Breast Cancer	involved_in	disease	0.95
Insulin Resistance	regulates	phenotype	0.95
ER+ Breast Cancer	involved_in	disease	0.95
Triple-Negative Breast Cancer	targets	disease	0.95
Non-Small Cell Lung Cancer	involved_in	disease	0.95
Cancer	contributes_to	disease	0.95
Breast Cancer	involved_in	disease	0.95
Cell Proliferation	regulates	process	0.95
Cell Survival	regulates	process	0.95
Cancer	associated_with	disease	0.95
Gastric Cancer	associated_with	disease	0.95
Triple-Negative Breast Cancer	contributes_to	disease	0.95
Glioblastoma Metabolism	upregulates	process	0.93
cell proliferation	regulates	process	0.93
NEUROINFLAMMATION	mediates	process	0.92
multiple myeloma	therapeutic_target	disease	0.92
triple-negative breast cancer	promotes	disease	0.92
Cell Proliferation	contributes_to	process	0.90
myeloma cell proliferation	activates	process	0.90
Breast Cancer Growth	contributes_to	phenotype	0.90
apoptosis	regulates	process	0.90
ferritinophagy	regulates	process	0.90
myeloma cell survival	promotes	process	0.90
Cancer	causes	disease	0.90
triple-negative breast cancer	regulates	disease	0.90
Tumor Growth	regulates	process	0.90
myeloma cell survival	promotes	process	0.90
Angiogenesis	promotes	process	0.90
multiple myeloma	implicated_in	disease	0.90
Autophagy	inhibits	process	0.90
Glioblastoma	upregulates	disease	0.90
Triple-negative breast cancer	implicated_in	disease	0.90
cell proliferation	regulates	process	0.90
angiogenesis	promotes	process	0.90
ER+ breast cancer	implicated_in	disease	0.90
Drug Resistance	contributes_to	phenotype	0.90
Endocrine Therapy Resistance	causes	phenotype	0.90
Pluripotent Stem Cells	regulates	cell_type	0.90
triple-negative breast cancer	associated_with	disease	0.90
apoptosis	regulates	process	0.90
myeloma cell proliferation	promotes	process	0.90
CDK4/6 Inhibitor Resistance	causes	phenotype	0.90
Cellular Differentiation	involved_in	process	0.90
triple-negative breast cancer	therapeutic_target	disease	0.90
Cell Growth	regulates	biological_process	0.90

Incoming (283)

Source	Relation	Type	Str
Alpelisib	inhibits	drug	0.95
Akt	involved_in	protein	0.95
Gomisin N	activates	compound	0.95
SYK	regulates	protein	0.95
Cordycepin	inhibits	compound	0.95
PI3K/Akt/mTOR Inhibitors	inhibits	drug	0.95
Capivasertib	inhibits	drug	0.95
mTOR	involved_in	protein	0.95
Paxalisib	inhibits	drug	0.95
BBR	inhibits	compound	0.93
Nobiletin	inhibits	compound	0.92
Non-coding RNAs	regulates	biomarker	0.90
Ly294002	inhibits	drug	0.90
Kinase Inhibitors	inhibits	drug	0.90
Polygonatum sibiricum polysaccharide	activates	compound	0.90
B.glomerulata	activates	drug	0.90
MTOR	component_of	protein	0.90
BBR	inhibits	drug	0.90
FBXO32	activates	protein	0.90
DNA Methylation	regulates	mechanism	0.90
kinase inhibitors	inhibits	drug	0.88
IRGM1	activates	protein	0.88
bone marrow microenvironment	activates	cell_type	0.88
PTEN	inhibits	gene	0.85
PIK3CA	activates	gene	0.85
Ginsenoside Rg3	inhibits	compound	0.85
Chrysotoxine	inhibits	compound	0.85
Kinase Inhibitors	inhibits	drug	0.85
IRGM1	upstream_of	protein	0.85
Cantharidin	inhibits	compound	0.85
Sijunzi Decoction	modulates	drug	0.85
STK11	regulates	gene	0.85
Osteoking	activates	drug	0.85
Chrysotoxine	inhibits	compound	0.85
AKT	upstream_of	protein	0.85
H. pylori	regulates	biomarker	0.85
Epstein-Barr Virus	regulates	biomarker	0.85
bone marrow microenvironment	activates	cell_type	0.82
Ginsenoside RG3	inhibits	compound	0.80
Cantharidin	inhibits	drug	0.80
Vinegar-processed Curcumae Rhizome	regulates	drug	0.80
Tumor Suppressor Gene Alteration	activates	mechanism	0.80
METFORMIN	inhibits	drug	0.80
INSULIN_RESISTANCE	impairs	phenotype	0.80
Oncogene Alteration	activates	mechanism	0.80
AKT	activates	gene	0.80
Gnetupendin A	activates	compound	0.80
THBS2	activates	gene	0.80
PDGF	regulates	gene	0.70
PDGF	activates	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PI3K/AKT/MTOR in their description or question text

No additional research found