Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CAMK2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Calcium/calmodulin-dependent protein kinase II alpha gene encoding a critical synaptic plasticity molecule with roles in LTP, memory, and neurodegeneration.
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| Gene Symbol | CAMK2A |
| Full Name | Calcium/Calmodulin-Dependent Protein Kinase II Alpha |
| Protein Type | Serine/Threonine Kinase |
| Function | Calcium/Calmodulin-Dependent Protein Kinase II alpha (CaMKIIα) is a serine/threonine kinase that serves as a central mediator of synaptic plasticity, learning, and memory |
| Molecular Weight | 54.1 kDa (monomer) |
| Pathways | Hepatic Mitochondrial Oxidation, Intrahepatic Lipolysis, Neuronal Regeneration, Neuroregeneration, epigenetic regulation |
| UniProt ID | [Q9UQM7](https://www.uniprot.org/uniprot/Q9UQM7) |
| GeneCards | CAMK2A |
| Human Protein Atlas | CAMK2A |
| Associated Diseases | Als, epilepsy, Ms, neuroscience |
| Known Drugs/Compounds | Cytosolic Calcium |
| Interactions | AND, ARC, ATM, BDNF, BRCA1, BRD4 |
| SciDEX Hypotheses | CaMKII-Dependent Synaptic Circuit Amplification |
| KG Connections | 148 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CAMK2A["CAMK2A"]
Ms{"Ms"}
CAMK2A -->|"associated with"| Ms
Parkinson{"Parkinson"}
CAMK2A -->|"associated with"| Parkinson
Als{"Als"}
CAMK2A -->|"associated with"| Als
CAMK2A -->|"expressed in"| Ms
Depression{"Depression"}
CAMK2A -->|"expressed in"| Depression
ALS{"ALS"}
CAMK2A -->|"associated with"| ALS
SNCA["SNCA"]
CAMK2A -->|"associated with"| SNCA
SLC6A3["SLC6A3"]
CAMK2A -->|"associated with"| SLC6A3
UBC["UBC"]
CAMK2A -->|"associated with"| UBC
HOMER1["HOMER1"]
CAMK2A -->|"associated with"| HOMER1
COMT["COMT"]
CAMK2A -->|"associated with"| COMT
GENES["GENES"]
CAMK2A -->|"associated with"| GENES
DRD2["DRD2"]
DRD2 -->|"associated with"| CAMK2A
FYN["FYN"]
FYN -->|"associated with"| CAMK2A
SRC["SRC"]
SRC -->|"associated with"| CAMK2A
CLOCK["CLOCK"]
CLOCK -->|"expressed in"| CAMK2A
BMAL1["BMAL1"]
BMAL1 -->|"expressed in"| CAMK2A
PER["PER"]
PER -->|"expressed in"| CAMK2A
UBC -->|"associated with"| CAMK2A
SNCA -->|"associated with"| CAMK2A
AND["AND"]
AND -->|"associated with"| CAMK2A
GENES -->|"associated with"| CAMK2A
COMT -->|"associated with"| CAMK2A
PARKINSON["PARKINSON"]
PARKINSON -->|"associated with"| CAMK2A
style CAMK2A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| ds-f2c28aed24a7 | provides_data_for | dataset | 1.00 |
| Hepatic Mitochondrial Oxidation | activates | process | 0.95 |
| hepatic mitochondrial oxidation | promotes | process | 0.90 |
| intrahepatic lipolysis | promotes | process | 0.90 |
| hepatic fat metabolism | mediates | process | 0.90 |
| Necroinflammation | involved_in | process | 0.90 |
| Neuroregeneration | involved_in | process | 0.90 |
| neuroregeneration | regulates | process | 0.85 |
| Neuronal Regeneration | involved_in | process | 0.85 |
| Intrahepatic Lipolysis | activates | process | 0.85 |
| gluconeogenesis | regulates | process | 0.85 |
| Gluconeogenesis | mediates | process | 0.80 |
| PARP1 | activates | gene | 0.65 |
| ALS | associated_with | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| MTOR | treats | gene | 0.65 |
| DNA | activates | gene | 0.65 |
| ALS | expressed_in | disease | 0.65 |
| Epilepsy | causes | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Huntington | expressed_in | disease | 0.65 |
| NEURON | expressed_in | cell_type | 0.65 |
| Ms | associated_with | disease | 0.65 |
| NEURONS | expressed_in | cell_type | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| neurotrophin signaling | participates_in | pathway | 0.65 |
| Depression | expressed_in | disease | 0.65 |
| Epilepsy | therapeutic_target | disease | 0.65 |
| DRD2 | associated_with | gene | 0.60 |
| SRC | associated_with | gene | 0.60 |
| NEURON | enhances | cell_type | 0.60 |
| FYN | associated_with | gene | 0.60 |
| COMT | associated_with | gene | 0.60 |
| HOMER1 | associated_with | gene | 0.60 |
| UBC | associated_with | gene | 0.60 |
| TNF | markers | gene | 0.60 |
| SLC6A3 | associated_with | gene | 0.60 |
| SNCA | associated_with | gene | 0.60 |
| NEURONS | markers | cell_type | 0.60 |
| PD | co_discussed | gene | 0.60 |
| GLUTAMATERGIC | activates | cell_type | 0.60 |
| Neural Progenitor | therapeutic_target | cell_type | 0.60 |
| MICROGLIA | markers | cell_type | 0.60 |
| GENES | associated_with | gene | 0.60 |
| Rb | therapeutic_target | protein | 0.60 |
| epilepsy | associated_with | disease | 0.60 |
| MTOR | therapeutic_target | gene | 0.60 |
| TNF | regulates | gene | 0.60 |
| MAPT | markers | gene | 0.60 |
| RHEB | causes | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ds-f2c28aed24a7 | data_in | dataset | 1.00 |
| h-62c78d8b | targets | hypothesis | 0.90 |
| Cytosolic Calcium | activates | compound | 0.90 |
| GPR39 | activates | receptor | 0.85 |
| BDNF | activates | gene | 0.65 |
| PER | expressed_in | gene | 0.60 |
| SNCA | associated_with | gene | 0.60 |
| MTOR | therapeutic_target | gene | 0.60 |
| RHEB | therapeutic_target | gene | 0.60 |
| RAS | therapeutic_target | gene | 0.60 |
| EPILEPSY | therapeutic_target | gene | 0.60 |
| UBC | associated_with | gene | 0.60 |
| BMAL1 | expressed_in | gene | 0.60 |
| SYN1 | expressed_in | gene | 0.60 |
| CLOCK | expressed_in | gene | 0.60 |
| EPILEPSY | causes | gene | 0.60 |
| HTT | expressed_in | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| PARKINSON'S DISEASE | associated_with | gene | 0.60 |
| DRD2 | associated_with | gene | 0.60 |
| FYN | associated_with | gene | 0.60 |
| SRC | associated_with | gene | 0.60 |
| COMT | associated_with | gene | 0.60 |
| HOMER1 | associated_with | gene | 0.60 |
| SLC6A3 | associated_with | gene | 0.60 |
| ARC | activates | gene | 0.55 |
| ATM | activates | gene | 0.55 |
| BRCA1 | activates | gene | 0.55 |
| BRD4 | activates | gene | 0.55 |
| ALS | co_discussed | entity | 0.50 |
| ALZHEIMER'S | co_discussed | entity | 0.50 |
| ALZHEIMER | co_discussed | entity | 0.50 |
| mTOR | associated_with | entity | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| CaMKII-Dependent Synaptic Circuit Amplification | 0.611 | neuroscience | Circuit-level neural dynamics in neurode |
Scientific analyses that reference this entity
neuroscience | 2026-04-03 | 66 hypotheses Top: 1.000
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Sex differences in CB1R-mediated cannabinoid analgesia in neuropathic | validation | neuropathic pain | 0.900 | 0.00 | C57BL/6J mice (8-12 weeks old) | proposed | N/A |
| Conditional CB1R knockout in mPFC CaMKIIα neurons | validation | neuropathic pain | 0.900 | 0.00 | CB1R-floxed mice with conditio | proposed | N/A |
| Electrophysiological analysis of mPFC-vlPAG synaptic transmission | exploratory | neuropathic pain | 0.850 | 0.00 | Mouse brain slices from C57BL/ | proposed | N/A |
| CB1R expression mapping in mPFC-vlPAG circuit | exploratory | neuropathic pain | 0.850 | 0.00 | GAD2-Cre-tdTomato mice, CB1R-i | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Chaperone-mediated autophagy as a sex-specific modulator of synaptic proteostasi [PMID:41358563] | Luo R | Autophagy | 2026 | 0 |
| The mPFC molecular clock mediates the effects of sleep deprivation on depression [PMID:41023421] | Gardner W, Sarrazin DH, Balzinger M, Mar | Mol Psychiatry | 2026 | 0 |
| Sexually dimorphic cannabinoid 1 receptors on CaMKIIα neurons in the medial pref [PMID:41380094] | Wang Q, Zhao J, Zhang X, Huang C, Li Y e | Pain | 2026 | 0 |
| A bioinspired anisotropic anti-inflammatory scaffold enhances spinal nerve regen [PMID:41737465] | Jiang M, Lu W, Zhuang J, Song J, Zhao Y | Mater Today Bio | 2026 | 0 |
| A multi-omics comparison unveils convergent and divergent antidepressant mechani [PMID:41796893] | Zhang J, Cai Y, Zhang P, Hao X, Guo B et | J Proteomics | 2026 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.00 · 2026-04-26
closed · Rounds: 4 · Score: 0.00 · 2026-04-26
closed · Rounds: 4 · Score: 0.00 · 2026-04-26
closed · Rounds: 4 · Score: 0.95 · 2026-04-03
Hypotheses and analyses mentioning CAMK2A in their description or question text
No additional research found