gene 971 words KG: CAMK2A
Contents

CAMK2A Gene

🧬 Gene Info
Gene SymbolCAMK2A
Full NameCalcium/Calmodulin-Dependent Protein Kinase II Alpha
Protein TypeSerine/Threonine Kinase
FunctionCalcium/Calmodulin-Dependent Protein Kinase II alpha (CaMKIIα) is a serine/threonine kinase that serves as a central mediator of synaptic plasticity, learning, and memory
Molecular Weight54.1 kDa (monomer)
PathwaysHepatic Mitochondrial Oxidation, Intrahepatic Lipolysis, Neuronal Regeneration, Neuroregeneration, epigenetic regulation
UniProt ID[Q9UQM7](https://www.uniprot.org/uniprot/Q9UQM7)
GeneCardsCAMK2A
Human Protein AtlasCAMK2A
Associated DiseasesAls, epilepsy, Ms, neuroscience
Known Drugs/CompoundsCytosolic Calcium
InteractionsAND, ARC, ATM, BDNF, BRCA1, BRD4
SciDEX HypothesesCaMKII-Dependent Synaptic Circuit Amplification
KG Connections148 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (11)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
Temporal TET2-Mediated Hydroxymethylation Cycling
Score: 0.66
KDM6A-Mediated H3K27me3 Rejuvenation
Score: 0.65
CYP46A1 Overexpression Gene Therapy
Score: 0.92
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82

Related Analyses (10)

Circuit-level neural dynamics in neurodegeneration
neuroscience · completed
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed

Related Experiments (5)

Bmal1 knockout in mPFC excitatory neurons
validation · proposed · Score: 0.95
Sex differences in CB1R-mediated cannabinoid analgesia in ne
validation · proposed · Score: 0.90
Conditional CB1R knockout in mPFC CaMKIIα neurons
validation · proposed · Score: 0.90
Electrophysiological analysis of mPFC-vlPAG synaptic transmi
exploratory · proposed · Score: 0.85
CB1R expression mapping in mPFC-vlPAG circuit
exploratory · proposed · Score: 0.85

See Also (15)

Packard Center for ALS Research
institution · KG edge: associated_with
BMAL1 (ARNTL) Gene
gene · KG edge: expressed_in
COMT Gene
gene · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
FYN — FYN Proto-Oncogene, Src Family Tyrosine Kinase
gene · KG edge: associated_with

Knowledge Graph (12 edges)

DRD2 associated_with CAMK2A
FYN associated_with CAMK2A
SRC associated_with CAMK2A
CAMK2A associated_with SNCA
CAMK2A associated_with SLC6A3
CAMK2A associated_with UBC
CAMK2A associated_with HOMER1
CAMK2A associated_with COMT
CAMK2A associated_with FYN
CAMK2A associated_with SRC

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