| Gene Symbol | CUL3 |
| Full Name | Cullin 3 |
| Chromosome | 2q36.2 |
| Protein Type | Scaffold Protein |
| Function | encodes a scaffold protein that nucleates Cullin-RING E3 ubiquitin ligase complexes (CRL3s). |
| Primary Expression | Ubiquitous, enriched in brain and testis |
| Pathways | Akt, Apoptosis, Oxidative Stress, Pi3K, Proteasome |
| UniProt ID | Q13618 |
| NCBI Gene ID | 8452 |
| Ensembl ID | ENSG00000036257 |
| OMIM | 603136 |
| GeneCards | CUL3 |
| Human Protein Atlas | CUL3 |
| N-terminal domain | Binds BTB-domain substrate adaptors (e.g., KEAP1, KLHL20, SPOP, KCTD13) |
| C-terminal cullin homology domain | Binds RBX1 (RING-finger protein), which recruits E2 ubiquitin-conjugating enzymes |
| Associated Diseases | ALS |
| Interactions | AKT, APOPTOSIS, AUTOPHAGY, BACH1, BCL2, BECN1 |
| KG Connections | 179 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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