| Gene Symbol | CD19 |
| Full Name | CD19 Molecule |
| Chromosome | 16p11.2 |
| Function | is a member of the immunoglobulin superfamily and functions as a critical signaling co-receptor on the surface of B cells. |
| Pathways | PI3K, PI3K Pathway, NF-κB |
| UniProt ID | P15391 |
| NCBI Gene ID | 933 |
| Ensembl ID | ENSG00000177455 |
| OMIM | 107741 |
| GeneCards | CD19 |
| Human Protein Atlas | CD19 |
| PI3K Pathway Activation | CD19 recruits PI3K p85 subunit, leading to Akt activation and metabolic reprogramming |
| Calcium Signaling | Facilitates PLCγ2 activation and intracellular calcium release |
| Survival Signaling | Promotes B-cell survival through NF-κB activation |
| Antibody Production | Critical for T-dependent antibody responses and germinal center formation |
| Associated Diseases | ALS, Autoimmune, Cancer, Inflammation, Lymphoma, Multiple Sclerosis |
| Known Drugs/Compounds | Inebilizumab-Cdon |
| Interactions | ACTB, AQP4, C5, CAT, CCL5, CD4 |
| KG Connections | 177 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
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