gene

LETM1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LETM1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

48Connections

0Hypotheses

0Analyses

41Outgoing

7Incoming

0Experiments

0Debates

Summary

LETM1 is a mitochondrial inner membrane protein that functions as a calcium/proton antiporter, essential for mitochondrial morphology, cristae structure, and implicated in neurodegeneration

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🧬 Gene Info

Gene Symbol	LETM1
Full Name	Leucine Zipper and EF-Hand Containing Transmembrane Protein 1
Chromosome	4p16.3
Function	encodes an essential mitochondrial inner membrane protein that plays critical roles in mitochondrial function, calcium homeostasis, and cellular metabolism.
Primary Expression	tissues with high metabolic demands, particularly the brain, cerebellum, heart, and skeletal mus
Molecular Weight	81 kDa
Amino Acids	739 aa
Exons	14
Pathways	oxidative stress response
Ensembl ID	ENSG00000168936
GeneCards	LETM1
Human Protein Atlas	LETM1
Associated Diseases	AD, ALI, AMI, cancer, diabetes
Interactions	OVERVIEW
KG Connections	48 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

LETM1 — Leucine Zipper and EF-Hand Containing Transmembrane Protein 1

gene · 1696 words

→

LETM1 Protein

protein · 594 words

→

Pathway Diagram

graph TD
    LETM1["LETM1"]
    Cancer{"Cancer"}
    LETM1 -->|"therapeutic target"| Cancer
    Neurodegeneration{"Neurodegeneration"}
    LETM1 -->|"therapeutic target"| Neurodegeneration
    Stroke{"Stroke"}
    LETM1 -->|"therapeutic target"| Stroke
    Ms{"Ms"}
    LETM1 -->|"therapeutic target"| Ms
    Heart_Failure{"Heart Failure"}
    LETM1 -->|"therapeutic target"| Heart_Failure
    Diabetes{"Diabetes"}
    LETM1 -->|"therapeutic target"| Diabetes
    LETM1 -->|"associated with"| Cancer
    LETM1 -->|"associated with"| Diabetes
    LETM1 -->|"associated with"| Heart_Failure
    LETM1 -->|"associated with"| Neurodegeneration
    LETM1 -->|"associated with"| Stroke
    LETM1 -->|"regulates"| Heart_Failure
    OVERVIEW["OVERVIEW"]
    OVERVIEW -->|"regulates"| LETM1
    MCU["MCU"]
    MCU -->|"regulates"| LETM1
    STROKE["STROKE"]
    STROKE -->|"regulates"| LETM1
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"regulates"| LETM1
    CANCER["CANCER"]
    CANCER -->|"regulates"| LETM1
    style LETM1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (41)

Target	Relation	Type	Str
Mitochondrial Calcium Transport	mediates	process	0.95
Mitochondrial Calcium Exchange	mediates	process	0.95
MITOCHONDRIAL CALCIUM EFFLUX	mediates	entity	0.95
Cancer	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Stroke	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Heart Failure	therapeutic_target	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Heart Failure	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Stroke	associated_with	disease	0.65
Stroke	regulates	disease	0.65
Cancer	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
Diabetes	regulates	disease	0.65
Heart Failure	regulates	disease	0.65
AND	regulates	gene	0.60
neurodegeneration	associated_with	disease	0.60
stroke	associated_with	disease	0.60
CANCER	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
STROKE	regulates	gene	0.60
oxidative stress response	participates_in	pathway	0.60
MCU	regulates	gene	0.60
OVERVIEW	regulates	gene	0.60
MCU	interacts_with	entity	0.60
Rb	therapeutic_target	protein	0.60
AMI	implicated_in	disease	0.50
muscular disorders	implicated_in	disease	0.50
ALI	implicated_in	disease	0.50
disease	implicated_in	disease	0.50
SS	implicated_in	disease	0.50
RA	implicated_in	disease	0.50
Ms	implicated_in	disease	0.50
diabetes	implicated_in	disease	0.50
AD	implicated_in	disease	0.50
cancer	implicated_in	disease	0.50
heart failure	implicated_in	disease	0.50

Incoming (7)

Source	Relation	Type	Str
STROKE	therapeutic_target	gene	0.60
OVERVIEW	regulates	gene	0.60
STROKE	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
CANCER	regulates	gene	0.60
MCU	regulates	gene	0.60
OVERVIEW	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning LETM1 in their description or question text

No additional research found