concept

THBS2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about THBS2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

86Connections

0Hypotheses

0Analyses

50Outgoing

15Incoming

0Experiments

0Debates

Summary

THBS2 is a concept in neurodegeneration research. Key relationships include: associated with, regulates, activates. Associated with ALS, Als, Cancer. Connected to 63 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	THBS2
Key Genes/Proteins	Actin, AKT, APP, BDNF, CANCER, CD4
Related Diseases	Als, ALS, Cancer, Carcinoma, Cirrhosis
Related Pathways	Akt, Angiogenesis

Pathway Diagram

graph TD
    THBS2["THBS2"]
    THBS2 -->|"regulates"| PI3K_AKT["PI3K/AKT"]
    THBS2 -->|"activates"| Ms["Ms"]
    THBS2 -->|"activates"| Cancer["Cancer"]
    THBS2 -->|"activates"| Tumor["Tumor"]
    THBS2 -->|"regulates"| Als["Als"]
    THBS2 -->|"target for"| Hepatitis["Hepatitis"]
    THBS2 -->|"target for"| Fibrosis["Fibrosis"]
    THBS2 -->|"target for"| Cirrhosis["Cirrhosis"]
    PI3K["PI3K"] -->|"activates"| THBS2
    CANCER["CANCER"] -->|"activates"| THBS2
    AKT["AKT"] -->|"activates"| THBS2
    CD4["CD4"] -->|"expressed in"| THBS2
    PDGFRA["PDGFRA"] -->|"regulates"| THBS2
    AND["AND"] -->|"regulates"| THBS2
    PDGFRB["PDGFRB"] -->|"regulates"| THBS2
    GLI1["GLI1"] -->|"regulates"| THBS2

Outgoing (71)

Target	Relation	Type	Str
PI3K/AKT/MTOR	activates	pathway	0.80
Tumor	activates	disease	0.75
Cancer	therapeutic_target	disease	0.75
CANCER	therapeutic_target	gene	0.70
AKT	activates	pathway	0.70
inhibitory synapse number	regulates	phenotype	0.70
Vasculogenic Mimicry	regulates	process	0.70
PI3K/AKT	regulates	pathway	0.70
AKT	associated_with	gene	0.70
Ms	regulates	disease	0.65
Ms	activates	disease	0.65
Cancer	activates	disease	0.65
Cancer	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	expressed_in	disease	0.65
Als	regulates	disease	0.65
Fibrosis	regulates	disease	0.65
Cancer	biomarker_for	disease	0.65
Liver Cancer	biomarker_for	disease	0.65
Nafld	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
ALS	regulates	disease	0.65
Fatty Liver	biomarker_for	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Cirrhosis	therapeutic_target	disease	0.65
CFTR	associated_with	gene	0.60
COL1A1	associated_with	gene	0.60
PDGFRA	regulates	gene	0.60
INFLAMMATION	associated_with	gene	0.60
CANCER	biomarker_for	gene	0.60
RAGE	therapeutic_target	gene	0.60
Stem Cell	regulates	cell_type	0.60
mTOR	activates	pathway	0.60
SPP1	associated_with	gene	0.60
GLI1	regulates	gene	0.60
P53	regulates	gene	0.60
Akt	associated_with	pathway	0.60
CTSK	expressed_in	gene	0.60
MARCKS	expressed_in	gene	0.60
IMMUNE INFILTRATION	expressed_in	gene	0.60
CANCER	expressed_in	gene	0.60
APP	associated_with	gene	0.60
PDGFRB	regulates	gene	0.60
Akt	activates	pathway	0.60
MIRNAS	associated_with	gene	0.60
PI3K	activates	gene	0.60

Incoming (15)

Source	Relation	Type	Str
PI3K	activates	gene	0.60
CANCER	activates	gene	0.60
AKT	activates	gene	0.60
PDGFRA	associated_with	gene	0.60
CD4	expressed_in	gene	0.60
PDGFRB	regulates	gene	0.60
GLI1	regulates	gene	0.60
PDGF	regulates	gene	0.60
PDGFRA	regulates	gene	0.60
RNA	activates	gene	0.60
ITGB1	activates	gene	0.60
BDNF	protects_against	gene	0.55
FGF2	protects_against	gene	0.55
GDNF	protects_against	gene	0.55
GFAP	protects_against	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning THBS2 in their description or question text

No additional research found