gene 883 words KG: DNAJC7
Contents

DnaJ Heat Shock Protein Family (Hsp40) Member C7

🧬 Gene Info
Gene SymbolDNAJC7
Full NameDnaJ Heat Shock Protein Family (Hsp40) Member C7
Chromosome12q24.31
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight55 kDa
Amino Acids70 aa
PathwaysAutophagy, Proteasome, Tdp-43, Ubiquitin-Proteasome
UniProt IDQ9H0U4
GeneCardsDNAJC7
Human Protein AtlasDNAJC7
J domainThe defining feature of Hsp40 proteins, approximately 70 amino acids, which interacts with and activates Hsp70 ATPase activity
Gly/Phe-rich regionFlexible region potentially involved in substrate binding
TPR domainTetratricopeptide repeat domain that mediates interactions with Hsp90 and other TPR-containing proteins
C-terminal client-binding regionVariable domain involved in substrate recognition
Associated DiseasesALS, Amyotrophic Lateral Sclerosis
InteractionsHSP90
KG Connections61 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (3)

Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Chaperone-Mediated APOE4 Refolding Enhancement
Score: 0.68

Related Analyses (5)

Protein aggregation cross-seeding across neurodegenerative d
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · completed
RNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived

Related Experiments (1)

ER-Golgi Secretory Pathway Dysfunction in PD - Experiment De
clinical · proposed · Score: 0.40

See Also (15)

Amyotrophic Lateral Sclerosis
redirect · KG edge: regulates
Apoptosis in Neurodegeneration
entity · KG edge: expressed_in
Genes
index · KG edge: expressed_in
BAG3 Gene
gene · KG edge: expressed_in
DNAJB1 Gene
gene · KG edge: expressed_in

Knowledge Graph (12 edges)

UBIQUITIN expressed_in DNAJC7
BAG3 expressed_in DNAJC7
UBC expressed_in DNAJC7
HSPD1 expressed_in DNAJC7
DNAJC7 expressed_in HSPA6
DNAJC7 expressed_in DNAJB1
DNAJC7 expressed_in IKBKB
DNAJC7 expressed_in HSPA1B
DNAJC7 expressed_in HSPE1
DNAJC7 expressed_in HSP90AB1

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