gene

CRH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CRH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

592Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

CRH is a gene implicated in neurodegeneration research. Key relationships include: activates, expressed in, associated with. Associated with ALI, ALS, ALZHEIMER. Connected to 189 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	CRH
Chromosome	8q13
Protein Type	Ligand
Target Class	Ligand
Function	The CRH gene encodes prepro-CRH, a precursor peptide that is processed to mature CRH.
Mechanism of Action	CRH receptor antagonist blocking stress hormone signaling
Primary Expression	brain regions involved in stress and emotion:
Druggability	Low (0.34)
Clinical Stage	Approved
Amino Acids	41 aa
Pathways	Apoptosis, Blood-Brain Barrier, Complement, HPA-axis, HPA_AXIS
UniProt ID	P06850
Ensembl ID	ENSG00000118271
GeneCards	CRH
Human Protein Atlas	CRH
Associated Diseases	Addiction, Alopecia Areata, Als, Alzheimer
Known Drugs/Compounds	dexamethasone
Interactions	ACTH, Actin, AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID
SciDEX Target	View Target Profile (10 clinical trials)
KG Connections	590 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: CRH — AlphaFold P06850 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (14)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CRH["CRH"] -->|"associated"| neurodegeneration["neurodegeneration"]
    CRH["CRH"] -->|"interacts"| NR3C1["NR3C1"]
    CRH["CRH"] -->|"interacts"| TNFA["TNFA"]
    CRH["CRH"] -->|"co discussed"| BDNF["BDNF"]
    CRH["CRH"] -->|"co discussed"| ULK1["ULK1"]
    CRH["CRH"] -->|"co discussed"| SNCA["SNCA"]
    NR3C1_1["NR3C1"] -->|"interacts"| CRH["CRH"]
    TNFA_2["TNFA"] -->|"interacts"| CRH["CRH"]
    BMAL1["BMAL1"] -->|"co discussed"| CRH["CRH"]
    CLOCK["CLOCK"] -->|"co discussed"| CRH["CRH"]
    style CRH fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (443)

Target	Relation	Type	Str
ACTH	activates	protein	1.00
Central Amygdala	expressed_in	cell_type	0.95
HPA-axis	regulates	pathway	0.95
ACTH	stimulates	protein	0.90
Stress-Induced Hyperglycemia	mediates	phenotype	0.90
Hypothalamic-Pituitary-Adrenal Axis	component_of	pathway	0.90
Hpa Axis	involved_in	pathway	0.90
thalamus	expressed_in	brain_region	0.90
hypothalamus	expressed_in	brain_region	0.90
CRHR1	activates	protein	0.87
HPA_AXIS	participates_in	pathway	0.87
Paraventricular Nucleus	expressed_in	cell_type	0.85
Post-Traumatic Stress Disorder	associated_with	disease	0.85
Alopecia Areata	associated_with	disease	0.85
Alcohol Intake	modulates	phenotype	0.85
Alopecia Areata	upregulates	disease	0.85
NR3C1	associated_with	gene	0.80
CeA	expressed_in	brain_region	0.80
neurons	associated_with	cell_type	0.80
neurons	activates	cell_type	0.80
oxidative stress response	participates_in	pathway	0.80
HPA Axis Homeostasis	regulates	process	0.80
Hypersexual Disorder	associated_with	disease	0.80
stress_response	activates	pathway	0.80
HPA_AXIS	regulates	pathway	0.76
GUT_DYSBIOSIS	causes	phenotype	0.72
APIR	expressed_in	brain_region	0.72
PVN	expressed_in	brain_region	0.72
serotonin	releases	neurotransmitter	0.70
unfolded protein response	participates_in	pathway	0.70
neurons	regulates	cell_type	0.70
cortex	expressed_in	brain_region	0.70
amygdala	expressed_in	brain_region	0.70
depression	associated_with	disease	0.70
stress response	regulates	process	0.70
Hypersexual Disorder	biomarker_for	disease	0.70
mast cells	regulates	cell_type	0.70
mast cells	activates	cell_type	0.70
neuroinflammation	activates	disease	0.70
SOCIAL_INTERACTION	inhibits	phenotype	0.68
BMA	activates	brain_region	0.68
SOCIAL_MOTIVATION	activates	phenotype	0.68
Ptsd	associated_with	disease	0.65
Ptsd	activates	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Opioid	associated_with	disease	0.65
Stroke	activates	disease	0.65
ALS	regulates	disease	0.65
Alzheimer	expressed_in	disease	0.65
Alzheimer	therapeutic_target	disease	0.65

Incoming (149)

Source	Relation	Type	Str
h-1e564178	targets	hypothesis	0.90
Stress	upregulates	process	0.90
PVN	produces	brain_region	0.87
DNA Methylation	regulates	mechanism	0.85
Familiar Context Stress	upregulates	process	0.85
STRESS	activates	phenotype	0.72
AVP	interacts_with	gene	0.70
OLFACTORY_CUES	activates	phenotype	0.64
ALZHEIMER	activates	disease	0.64
NR3C1	interacts_with	gene	0.61
TNFA	interacts_with	gene	0.61
BDNF	associated_with	gene	0.60
CHRM4	expressed_in	gene	0.60
MYO7A	activates	gene	0.60
GRM2	expressed_in	gene	0.60
WNT1	activates	gene	0.60
BDNF	upregulates	entity	0.60
NPY	regulates	gene	0.60
NR3C1	associated_with	gene	0.60
FKBP5	interacts_with	gene	0.60
AVP	expressed_in	gene	0.60
POMC	expressed_in	gene	0.60
CRHR1	expressed_in	gene	0.60
NTS	regulates	gene	0.60
APOPTOSIS	activates	gene	0.60
ASTROCYTE	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
GABA	activates	gene	0.60
GABA	regulates	gene	0.60
IL-33	associated_with	gene	0.60
TSLP	associated_with	gene	0.60
BDNF	regulates	gene	0.60
BDNF	enhances	gene	0.60
CRHR1	interacts_with	gene	0.60
TNF	associated_with	gene	0.60
JUN	associated_with	gene	0.60
autophagy	inhibits	pathway	0.60
IL18BP	inhibits	gene	0.60
autophagy	regulates	pathway	0.60
RAS	activates	gene	0.60
INFLAMMATION	regulates	gene	0.60
IL18	activates	gene	0.60
RAMP1	inhibits	gene	0.60
FKBP5	activates	gene	0.60
TNF	activates	gene	0.60
NPY	activates	gene	0.60
AGING	activates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
QRFP	causes	gene	0.60
ANXIETY	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Digital biomarkers and AI-driven early detection of neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.756

Digital biomarkers and AI-driven early detection of neurodegeneration

neurodegeneration | 2026-04-01 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

Can speech, gait, retinal imaging, sleep, and smartphone data detect neurodegene

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

What are the mechanisms underlying digital biomarkers and ai-driven early detect

closed · Rounds: 4 · Score: 0.86 · 2026-04-01

Related Research

Hypotheses and analyses mentioning CRH in their description or question text

No additional research found

CRH

Understanding Entity Pages

Summary

Wiki Pages (14)

CRH Gene

CRH-Positive Hippocampal Neurons

Hypothalamic CRH Neurons

Corticotropin Releasing Hormone (CRH)

Amygdala CRH Neurons

Paraventricular Hypothalamic CRH Neurons

Corticotropin-Releasing Hormone (CRH) Neurons

Hypothalamic CRH Neurons in Stress-Related Disorders

CRHR1

Paraventricular Nucleus CRH Neurons

CRH Neurons

Paraventricular Nucleus CRH Neurons

CRH Neurons - Expanded

Paraventricular Nucleus (PVN) CRH Neurons

Pathway Diagram

Outgoing (443)

Incoming (149)

Targeting Hypotheses (0)

Mentioning Analyses (2)

Digital biomarkers and AI-driven early detection of neurodegeneration

Digital biomarkers and AI-driven early detection of neurodegeneration

Experiments (0)

Related Papers (0)

Debates (2)

Can speech, gait, retinal imaging, sleep, and smartphone data detect neurodegene

What are the mechanisms underlying digital biomarkers and ai-driven early detect

Related Research