Contents

CRH Gene

🧬 Gene Info

Gene Symbol	CRH
Chromosome	8q13
Protein Type	Ligand
Target Class	Ligand
Function	The CRH gene encodes prepro-CRH, a precursor peptide that is processed to mature CRH.
Mechanism of Action	CRH receptor antagonist blocking stress hormone signaling
Primary Expression	brain regions involved in stress and emotion:
Druggability	Low (0.34)
Clinical Stage	Approved
Amino Acids	41 aa
Pathways	Apoptosis, Blood-Brain Barrier, Complement, HPA-axis, HPA_AXIS
UniProt ID	P06850
Ensembl ID	ENSG00000118271
GeneCards	CRH
Human Protein Atlas	CRH
Associated Diseases	Addiction, Alopecia Areata, Als, Alzheimer
Known Drugs/Compounds	dexamethasone
Interactions	ACTH, Actin, AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID
SciDEX Target	View Target Profile (10 clinical trials)
KG Connections	601 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

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