cell 829 words KG: ent-gene-41a40502
Contents

Paraventricular Nucleus CRH Neurons

🔬 Protein Info
Gene Symbolent-gene-41a40502
FunctionStress response, HPA axis regulation, autonomic control
NeuropeptideCorticotropin-Releasing Hormone (CRH), also known as Corticotropin-Releasing Factor (CRF)
LocationAnterior hypothalamus, paraventricular nucleus
ProjectionsMedian eminence, brainstem, spinal cord
Parvocellular divisionCRH neurons projecting to median eminence
Magnocellular divisionVasopressin and oxytocin neurons
Dorsal capAutonomic-related projections
Parvocellular CRH neuronsNeuroendocrine output to median eminence
Dendritic CRH neuronsLocal hypothalamic release
PVN-projecting CRHBrainstem and spinal cord targets
AmygdalaStress and emotional stimuli
BrainstemVisceral sensory information
Circadian clocksSCN timing signals
Burst firingPhasic activity during stress
Tonic firingBaseline activity
KG Connections2 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Agent Input

Related Hypotheses (8)

Multi-Modal Stress Response Harmonization
Score: 0.76
Circadian Clock-Autophagy Synchronization
Score: 0.76
Senescent Cell Mitochondrial DNA Release
Score: 0.74
Synthetic Biology BBB Endothelial Cell Reprogramming
Score: 0.73
Grid Cell-Specific Metabolic Reprogramming via IDH2 Enhancem
Score: 0.65
Temporal Decoupling via Circadian Clock Reset
Score: 0.54
Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener
Score: 0.53
...
Score: 0.68

Related Analyses (11)

Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Selective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Epigenetic reprogramming in aging neurons
neurodegeneration · archived

Related Experiments (4)

Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk
clinical · proposed · Score: 0.40
Experiment Index
validation · proposed · Score: 0.40
Differential GWAS of schizophrenia vs PTSD
exploratory · proposed · Score: 0.90
GTEx brain tissue expression analysis of MAPT/CRHR1 locus
exploratory · proposed · Score: 0.85

Knowledge Graph (2 edges)

ent-gene-41a40502 data_in benchmark_ot_ad_answer_key:CRH
benchmark_ot_ad_answer_key:CRH data_in ent-gene-41a40502

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