| Gene Symbol | CRHR1 |
| Aliases | Corticotropin Releasing Hormone Receptor 1 |
| Protein Type | Receptor |
| Function | The receptor consists of |
| Primary Expression | brain regions involved in stress, emotion, and memory regulation, including the cortex, hippocampus, amygdala, and pituitary gland |
| Amino Acids | 444 aa |
| Pathways | Autophagy, Er Stress, Hpa Axis, Immune Response, MAPK signaling |
| Ensembl ID | ENSG00000120088 |
| GeneCards | CRHR1 |
| Human Protein Atlas | CRHR1 |
| N-terminal extracellular domain | Contains the CRH-binding site |
| Seven transmembrane domains | Typical GPCR structure |
| C-terminal intracellular domain | Couples to G proteins and interacts with downstream effectors |
| HPA axis hyperactivity | Depressed patients often show elevated CRH levels and increased CRHR1 expression |
| Genetic associations | Polymorphisms in CRHR1 have been linked to MDD susceptibility and treatment response |
| Associated Diseases | Addiction, Alzheimer's disease, Depression, Dysbiosis, Hypersexual Disorder, Ms |
| Interactions | AND, ANXIETY, App, AUTOPHAGY, Bdnf, BDNF |
| KG Connections | 143 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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