protein

INTERLEUKIN-18

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about INTERLEUKIN-18: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

7Outgoing

3Incoming

0Experiments

0Debates

Summary

Page for Interleukin-18 Protein

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🔬 Protein Info

Gene Symbol	INTERLEUKIN
GeneCards	INTERLEUKIN
Human Protein Atlas	INTERLEUKIN
Associated Diseases	Fibrosis, Als, Cancer, Multiple Sclerosis, Neuroinflammation, Neurodegeneration
KG Connections	4 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

flowchart TD
    INTERLEUKIN_18(["INTERLEUKIN-18"])
    INFLAMMASOME("INFLAMMASOME")
    CYTOKINES("CYTOKINES")
    Pyroptosis["Pyroptosis"]
    GENE_EXPRESSION("GENE EXPRESSION")
    Insulin_Resistance["Insulin Resistance"]
    ANGPT1("ANGPT1")
    Differentiation("Differentiation")
    INSULIN("INSULIN")
    LDLR(["LDLR"])

    INTERLEUKIN_18 -->|"activates"| INFLAMMASOME
    INTERLEUKIN_18 -->|"activates"| CYTOKINES
    INTERLEUKIN_18 -->|"activates"| Pyroptosis
    INTERLEUKIN_18 -->|"expressed in"| GENE_EXPRESSION
    INTERLEUKIN_18 -->|"activates"| Insulin_Resistance
    INTERLEUKIN_18 -->|"activates"| ANGPT1
    INTERLEUKIN_18 -->|"activates"| Differentiation
    INTERLEUKIN_18 -->|"activates"| INSULIN
    LDLR -->|"expressed in"| INTERLEUKIN_18

    style INTERLEUKIN_18 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (7)

Target	Relation	Type	Str
Mitochondrial Dysfunction Gene Expression	interacts_with	process	0.80
Insulin Resistance	activates	disease	0.50
ANGPT1	activates	concept	0.50
INSULIN	activates	concept	0.50
GENE EXPRESSION	expressed_in	concept	0.50
CYTOKINES	activates	concept	0.50
Pyroptosis	activates	pathway	0.50

Incoming (3)

Source	Relation	Type	Str
Caspase-1	activates	enzyme	0.90
ACE	interacts_with	gene	0.80
LDLR	expressed_in	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning INTERLEUKIN-18 in their description or question text

No additional research found