| Gene Symbol | CASPASE1 |
| Aliases | CASPASE1PROTEIN |
| Function | Caspase-1 (interleukin-1β-converting enzyme, ICE) is the prototypical inflammatory caspase, playing a central role in innate immunity and inflammatory cell death (pyroptosis) |
| Subcellular Localization | Cytosol, inflammasome complex |
| Molecular Weight | 45 kDa (pro-form), 20/10 kDa (cleaved subunits) |
| UniProt ID | [P29466](https://www.uniprot.org/uniprot/P29466) |
| GeneCards | CASPASE1 |
| Human Protein Atlas | CASPASE1 |
| Pro-IL-1β → IL-1β | Caspase-1 cleaves the 31 kDa pro-IL-1β at D116-A117, releasing the 17 kDa mature IL-1β. In the brain, IL-1β at physiological levels regulates synaptic plasticity, sleep, and fever response |
| Pro-IL-18 → IL-18 | Caspase-1 cleaves pro-IL-18 at D36-Y37. Mature IL-18 modulates IFN-γ production by T cells and NK cells, contributing to CNS immune surveillance[@bhatt1994] |
| Associated Diseases | ALS |
| KG Connections | 10 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!