| Gene Symbol | VHL |
| Aliases | VHLPROTEIN |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | most tissues: |
| Subcellular Localization | Cytoplasm; nucleus under certain conditions and plays a significant role in the pathogenesis of [Alzheimer's Disease](/d |
| Molecular Weight | 19.5 kDa |
| Pathways | Mtor, Pi3K, Dna Methylation, Akt, Angiogenesis |
| Ensembl ID | ENSG00000196511 |
| GeneCards | VHL |
| Human Protein Atlas | VHL |
| Normoxia | VHL binds hydroxylated HIF-α, leading to ubiquitination and proteasomal degradation |
| Hypoxia | HIF-α escapes VHL recognition, accumulates, and activates transcription of adaptive genes |
| Target genes | VEGF (angiogenesis), EPO (erythropoiesis), GLUT1 (glucose transport), and more |
| Associated Diseases | Als, cancer, Carcinoma, Cardiovascular |
| Interactions | ACETYL-COA, ACLY, AKT, AND, APOE4, ATG14L |
| KG Connections | 280 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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