gene

CHMP2A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHMP2A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

67Connections

1Hypotheses

0Analyses

50Outgoing

13Incoming

0Experiments

0Debates

Summary

CHMP2A (Charged Multivesicular Body Protein 2A) - ESCRT-III complex component involved in endosomal sorting, autophagy, and neurodegeneration

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🧬 Gene Info

Gene Symbol	CHMP2A
Aliases	Charged Multivesicular Body Protein 2A
Chromosome	19q13.43
Function	is a core member of the ESCRT-III (Endosomal Sorting Complex Required for Transport III) machinery, which performs several critical cellular functions
Primary Expression	Ubiquitous, highest in brain and spinal cord
Molecular Weight	25 kDa
Amino Acids	224 aa
Pathways	Protein Aggregation
UniProt ID	O43633
NCBI Gene ID	26986
Ensembl ID	ENSG00000130724
GeneCards	CHMP2A
Human Protein Atlas	CHMP2A
Associated Diseases	Inflammation, multiple sclerosis, Necroptosis, Neurodegeneration, Neuroinflammation
Interactions	ALZHEIMER, App, CHMP2B, CHMP3, CHMP4B, CHMP6
KG Connections	67 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CHMP2A — AlphaFold O43633 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

CHMP2A

gene · 1384 words

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Pathway Diagram

graph TD
    CHMP2A["CHMP2A"]
    Alzheimer{"Alzheimer"}
    CHMP2A -->|"activates"| Alzheimer
    Dementia{"Dementia"}
    CHMP2A -->|"activates"| Dementia
    Als{"Als"}
    CHMP2A -->|"activates"| Als
    Frontotemporal_Dementia{"Frontotemporal Dementia"}
    CHMP2A -->|"activates"| Frontotemporal_Dementia
    Ftd{"Ftd"}
    CHMP2A -->|"activates"| Ftd
    ALS{"ALS"}
    CHMP2A -->|"activates"| ALS
    CHMP2B["CHMP2B"]
    CHMP2A -->|"activates"| CHMP2B
    CHMP6["CHMP6"]
    CHMP2A -->|"activates"| CHMP6
    Protein_Aggregation(["Protein Aggregation"])
    CHMP2A -->|"activates"| Protein_Aggregation
    neurodegeneration["neurodegeneration"]
    CHMP2A -->|"implicated in"| neurodegeneration
    CHMP6 -->|"activates"| CHMP2A
    CHMP2B -->|"activates"| CHMP2A
    GENES["GENES"]
    GENES -->|"activates"| CHMP2A
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"activates"| CHMP2A
    ALZHEIMER["ALZHEIMER"]
    ALZHEIMER -->|"activates"| CHMP2A
    DEMENTIA["DEMENTIA"]
    DEMENTIA -->|"activates"| CHMP2A
    TAU["TAU"]
    TAU -->|"activates"| CHMP2A
    AND["AND"]
    AND -->|"activates"| CHMP2A
    style CHMP2A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (54)

Target	Relation	Type	Str
Tau Aggregation Propagation	promotes	process	0.95
tau aggregation propagation	suppresses	process	0.90
CHMP2B	interacts_with	gene	0.80
Tumor	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Dementia	stabilizes	disease	0.65
Alzheimer	stabilizes	disease	0.65
Als	stabilizes	disease	0.65
Frontotemporal Dementia	stabilizes	disease	0.65
ALS	activates	disease	0.65
Necroptosis	associated_with	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Multiple Sclerosis	associated_with	disease	0.65
Frontotemporal Dementia	activates	disease	0.65
Ftd	activates	disease	0.65
Neuroinflammation	associated_with	disease	0.65
Alzheimer	activates	disease	0.65
Dementia	activates	disease	0.65
Als	activates	disease	0.65
FTD	activates	entity	0.60
DEMENTIA	activates	gene	0.60
INFLAMMATION	associated_with	gene	0.60
VESICLE TRAFFICKING	associated_with	gene	0.60
Myelination	inhibits	pathway	0.60
Neuroinflammatory	associated_with	pathway	0.60
CHMP4B	interacts_with	protein	0.60
TAU	activates	entity	0.60
ALZHEIMER	activates	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
neurons	expressed_in	cell_type	0.60
multiple sclerosis	associated_with	disease	0.60
oligodendrocytes	expressed_in	cell_type	0.60
CHMP2B	activates	gene	0.60
CHMP6	activates	gene	0.60
TNF	associated_with	gene	0.60
Rb	activates	protein	0.60
necroptosis	participates_in	pathway	0.60
Raf	associated_with	protein	0.60
App	inhibits	protein	0.60
frontotemporal dementia	activates	disease	0.60
CHMP4B	regulates	gene	0.60
MLKL	regulates	gene	0.60
Neuron	interacts_with	cell_type	0.60
Protein Aggregation	activates	pathway	0.60
cortex	expressed_in	brain_region	0.60
CHMP3	interacts_with	gene	0.55
ESCRT-III	interacts_with	gene	0.55
CHMP6	interacts_with	gene	0.55
Cortex	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55

Incoming (13)

Source	Relation	Type	Str
TAU	activates	gene	0.60
GENES	activates	gene	0.60
ALZHEIMER	stabilizes	gene	0.60
DEMENTIA	stabilizes	gene	0.60
TNF	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
DEMENTIA	activates	gene	0.60
NEURODEGENERATION	associated_with	gene	0.60
NEUROINFLAMMATION	associated_with	gene	0.60
CHMP6	activates	gene	0.60
CHMP2B	activates	gene	0.60
TNF	activates	gene	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
CHMP2B vs. CHMP2A Subunit Targeting Creates a Therapeutic Wi	0.330	neurodegeneration	What is the therapeutic window between t

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning CHMP2A in their description or question text

No additional research found