entity

CDK5/p25

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDK5/p25: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

2Hypotheses

3Analyses

5Outgoing

1Incoming

0Experiments

4Debates

No AI portrait yet

Outgoing (5)

Target	Relation	Type	Str
tau phosphorylation	causes	process	0.90
tau phosphorylation	regulates	process	0.70
PSD-95 phosphorylation	activates	mechanism	0.70
synaptic dysfunction	therapeutic_target_for	phenotype	0.70
synaptic proteome remodeling	regulates	mechanism	0.70

Incoming (1)

Source	Relation	Type	Str
Aβ42 oligomers	activates	protein	0.70

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Aβ42 oligomers drive TDP-43 phosphorylation at s409/410 thro	0.595	neurodegeneration	What mechanisms drive TDP-43 pathology s
Cdk5/p25-PSD-95 Phosphorylation Disrupts Synaptic Scaffoldin	0.455	neurodegeneration	Quantitative proteomics of the aging syn

Mentioning Analyses (3)

Scientific analyses that reference this entity

Does tau dendritic missorting persist independently after Aβ clearance, maintain

neurodegeneration | 2026-04-25 | 7 hypotheses Top: 0.740

What mechanisms drive TDP-43 pathology specifically in Alzheimer's disease versu

neurodegeneration | 2026-04-07 | 3 hypotheses Top: 0.595

Quantitative proteomics of the aging synapse in early Alzheimer disease

neurodegeneration | 2026-04-04 | 3 hypotheses Top: 0.455

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (4)

Multi-agent debates referencing this entity

Does tau dendritic missorting persist independently after Aβ clearance, maintain

closed · Rounds: 4 · Score: 0.65 · 2026-04-25

TDP-43 inclusions occur in AD, ALS, and FTLD but the pathogenic mechanisms leadi

closed · Rounds: 4 · Score: 0.70 · 2026-04-21

What are the critical protein expression changes and post-translational modifica

closed · Rounds: 4 · Score: 0.68 · 2026-04-12

What are the critical protein expression changes and post-translational modifica

closed · Rounds: 4 · Score: 0.56 · 2026-04-11

Related Research

Hypotheses and analyses mentioning CDK5/p25 in their description or question text

No additional research found