| Gene Symbol | TRKA |
| Chromosome | 1q23.1 |
| Protein Family | Trk family (TrkA, TrkB, TrkC) |
| Protein Type | Receptor |
| Function | is a high-affinity receptor tyrosine kinase for nerve growth factor (NGF), encoded by the NTRK1 gene on chromosome 1q21-22. |
| Primary Expression | basal forebrain cholinergic neurons (BFCNs), which are the primary source of acetylcholine to the hippocampus and neocortex |
| Subcellular Localization | </th><td>Plasma membrane, endosomes, retrograde signaling endosomes</td></tr> |
| Molecular Weight | 140 kDa |
| Amino Acids | 796 aa |
| Exons | 17 |
| Pathways | PI3K |
| GeneCards | TRKA |
| Human Protein Atlas | TRKA |
| ATP-binding site | Critical for catalytic activity and drug targeting |
| Tyrosine autophosphorylation sites | Tyr490, Tyr670, Tyr674, Tyr675 (major autophosphorylation sites) |
| Associated Diseases | Alzheimer, Alzheimer'S Disease, disease, Pain |
| Interactions | Actin, AGING, Akt, AKT, ALZHEIMER, ALZHEIMER'S DISEASE |
| KG Connections | 114 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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