gene 1,035 words KG: TRKA
Contents

TRKA Gene

🧬 Gene Info
Gene SymbolTRKA
Chromosome1q23.1
Protein FamilyTrk family (TrkA, TrkB, TrkC)
Protein TypeReceptor
Functionis a high-affinity receptor tyrosine kinase for nerve growth factor (NGF), encoded by the NTRK1 gene on chromosome 1q21-22.
Primary Expressionbasal forebrain cholinergic neurons (BFCNs), which are the primary source of acetylcholine to the hippocampus and neocortex
Molecular Weight140 kDa
Amino Acids796 aa
Exons17
PathwaysPI3K
GeneCardsTRKA
Human Protein AtlasTRKA
Associated DiseasesAlzheimer, Alzheimer'S Disease, disease, Pain
InteractionsActin, AGING, Akt, AKT, ALZHEIMER, ALZHEIMER'S DISEASE
KG Connections118 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (4)

CYP46A1 Overexpression Gene Therapy
Score: 0.92
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Ganglioside Rebalancing Therapy
Score: 0.69

Related Analyses (3)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (1)

Neural Stem Cell Therapy for Alzheimer's Disease
clinical · proposed · Score: 0.40

See Also (10)

Myelin Basic Protein (MBP) - Biomarker
biomarker · KG edge: transports
NeuRon Therapeutics
company · KG edge: activates
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: therapeutic_target
NGF (Redirect)
redirect · KG edge: activates
BDNF Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

TRKA interacts_with NRP1
TRKA interacts_with NGF
TRKA inhibits GAIN
TRKA regulates CASP3
NGF binds_to TRKA
NGF contributes_to TRKA
APP interacts_with TRKA
TAU regulates TRKA
TRKA activates NGF
TRKA therapeutic_target NGF

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