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gene 785 words KG: SYP
Contents

SYP Gene

🧬 Gene Info
Gene SymbolSYP
Full NameSynaptophysin
ChromosomeXp11.23
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight38 kDa
Amino Acids313 aa
Exons4
PathwaysOxidative Stress
UniProt ID[P08247](https://www.uniprot.org/uniprot/P08247)
Ensembl IDENSG00000157193
OMIM313475
GeneCardsSYP
Human Protein AtlasSYP
Associated DiseasesAlzheimer, Motor function, Motor function recovery, neurodegeneration
Known Drugs/Compoundsrapamycin
InteractionsACHE, ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMPK, AMYLOID
SciDEX HypothesesAge-driven synaptic gene silencing precedes neuron
KG Connections442 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (7)

Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82GFAP-Positive Reactive Astrocyte Subtype Delineation
Score: 0.75CYP46A1 Overexpression Gene Therapy
Score: 0.73Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Mitochondrial RNA Granule Rescue Pathway
Score: 0.66Epigenetic Memory Reprogramming for Alzheimer's Disease
Score: 0.61Synaptic Vesicle Tau Capture Inhibition
Score: 0.58

Related Analyses (5)

Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completedRNA binding protein dysregulation across ALS FTD and AD
neurodegeneration · archivedCRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · archivedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (7)

AMPK (AMP-Activated Protein Kinase)
entity · KG edge: activatesApoptosis in Neurodegeneration
entity · KG edge: associated_withAmyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activatesADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: regulatesAPP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: regulates

Knowledge Graph (12 edges)

SYP interacts_with SYNCRIP
SYNCRIP interacts_with SYP
PANX1 regulates SYP
S100B regulates SYP
RELB regulates SYP
P2RY1 regulates SYP
CASP3 regulates SYP
SOCS3 regulates SYP
TRPA1 regulates SYP
CXCL2 regulates SYP

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