Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about STEM CELL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | STEM CELL |
Knowledge base pages for this entity
graph TD
STEM_CELL["STEM CELL"]
autophagy["autophagy"] -->|"regulates"| STEM_CELL
ABCA1["ABCA1"] -->|"expressed in"| STEM_CELL
MTOR["MTOR"] -->|"expressed in"| STEM_CELL
P62["P62"] -->|"expressed in"| STEM_CELL
LC3["LC3"] -->|"expressed in"| STEM_CELL
APOE["APOE"] -->|"expressed in"| STEM_CELL
SQSTM1["SQSTM1"] -->|"expressed in"| STEM_CELL
LDL["LDL"] -->|"expressed in"| STEM_CELL
AMPK["AMPK"] -->|"expressed in"| STEM_CELL
ACTB["ACTB"] -->|"expressed in"| STEM_CELL| Target | Relation | Type | Str |
|---|---|---|---|
| Inflammatory Bowel Disease | activates | disease | 0.50 |
| STEM CELLS | regulates | concept | 0.50 |
| RUNX2 | activates | concept | 0.50 |
| STEM CELLS | activates | concept | 0.50 |
| GENE EXPRESSION | regulates | concept | 0.50 |
| Cell Division | regulates | pathway | 0.50 |
| Telomere | activates | pathway | 0.50 |
| disease | regulates | disease | 0.50 |
| ALZHEIMER'S | regulates | concept | 0.50 |
| Telomere | regulates | pathway | 0.50 |
| Proteostasis | regulates | process | 0.50 |
| Cellular Senescence | regulates | cell_type | 0.50 |
| CELL DEATH | activates | concept | 0.50 |
| PARKINSON'S | associated_with | concept | 0.50 |
| INTERNEURON | associated_with | concept | 0.50 |
| DOPAMINERGIC | activates | concept | 0.50 |
| DOPAMINERGIC NEURONS | activates | concept | 0.50 |
| Macrophage | activates | cell_type | 0.50 |
| MACROPHAGES | activates | concept | 0.50 |
| CYTOKINE | activates | concept | 0.50 |
| disease | inhibits | disease | 0.50 |
| ALZHEIMER'S | inhibits | concept | 0.50 |
| Cognitive Impairment | inhibits | phenotype | 0.50 |
| TAU TANGLES | protects_against | concept | 0.50 |
| REMYELINATION | activates | concept | 0.50 |
| Spinal Cord | expressed_in | brain_region | 0.50 |
| White Matter | expressed_in | brain_region | 0.50 |
| Substantia Nigra | expressed_in | brain_region | 0.50 |
| CYP1A1 | activates | concept | 0.50 |
| COLORECTAL CANCER | activates | disease | 0.50 |
| Microrna | activates | pathway | 0.50 |
| ENDOTHELIAL | activates | concept | 0.50 |
| Cortex | activates | brain_region | 0.50 |
| Infection | associated_with | disease | 0.50 |
| CARDIOVASCULAR DISEASE | associated_with | concept | 0.50 |
| STEM CELLS | interacts_with | concept | 0.50 |
| Sepsis | activates | disease | 0.50 |
| DNA DAMAGE | inhibits | concept | 0.50 |
| Dysbiosis | inhibits | disease | 0.50 |
| Telomere | inhibits | pathway | 0.50 |
| NEURONS | associated_with | concept | 0.50 |
| Cellular Senescence | associated_with | cell_type | 0.50 |
| NEURONS | inhibits | concept | 0.50 |
| CELL PROLIFERATION | activates | concept | 0.50 |
| PARKINSON'S | activates | concept | 0.50 |
| Glioma | associated_with | disease | 0.50 |
| Thalamus | expressed_in | brain_region | 0.50 |
| Epithelial Cell | activates | cell_type | 0.50 |
| Reactive Oxygen Species | activates | process | 0.50 |
| RAPAMYCIN | activates | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| OVERVIEW | therapeutic_target | gene | 1.00 |
| Als | inhibits | disease | 1.00 |
| Parkinson | activates | disease | 1.00 |
| MITOCHONDRIA | activates | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| PARKINSON | activates | gene | 1.00 |
| DNA | inhibits | gene | 1.00 |
| MICROGLIA | activates | gene | 1.00 |
| PI3K | regulates | gene | 1.00 |
| MTOR | therapeutic_target | gene | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| AGING | activates | gene | 1.00 |
| PARKINSON'S DISEASE | activates | gene | 1.00 |
| Aging | therapeutic_target | disease | 1.00 |
| AGING | therapeutic_target | gene | 1.00 |
| ALZHEIMER | activates | gene | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| CANCER | associated_with | gene | 1.00 |
| Tumor | activates | disease | 1.00 |
| ALZHEIMER'S DISEASE | activates | gene | 1.00 |
| P53 | activates | gene | 1.00 |
| Cancer | therapeutic_target | disease | 1.00 |
| GENES | activates | gene | 1.00 |
| Cancer | activates | disease | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| NEURON | activates | gene | 1.00 |
| AKT | therapeutic_target | gene | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| TAU | activates | gene | 1.00 |
| Cancer | associated_with | disease | 1.00 |
| Als | associated_with | disease | 1.00 |
| NEURODEGENERATION | activates | gene | 1.00 |
| NEURODEGENERATIVE DISEASES | therapeutic_target | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| Als | activates | disease | 1.00 |
| Aging | activates | disease | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| ASTROCYTE | activates | gene | 1.00 |
| ASTROCYTES | activates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| Inflammation | activates | disease | 1.00 |
| PARKINSON'S DISEASE | therapeutic_target | gene | 1.00 |
| BAX | activates | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| DNA | activates | gene | 1.00 |
| AKT | activates | gene | 1.00 |
| Neurodegeneration | therapeutic_target | disease | 1.00 |
| PARKINSON | therapeutic_target | gene | 1.00 |
| AGING | inhibits | gene | 1.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning STEM CELL in their description or question text
No additional research found