Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about DGAT1 AND SOAT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | DGAT1 AND SOAT1 |
| Key Genes/Proteins | AND, DGAT1, RNA, SOAT1 |
| Related Pathways | Cholesterol, Lipid Metabolism |
graph TD
DGAT1_AND_SOAT1[DGAT1 AND SOAT1]
DGAT1_AND_SOAT1 -->|inhibits| SOAT1[SOAT1]
DGAT1_AND_SOAT1 -->|inhibits| DGAT1[DGAT1]
DGAT1_AND_SOAT1 -->|inhibits| Lipid_Metabolism[Lipid Metabolism]
DGAT1_AND_SOAT1 -->|inhibits| AND[AND]
DGAT1_AND_SOAT1 -->|inhibits| Cholesterol[Cholesterol]
DGAT1_AND_SOAT1 -->|inhibits| RNA[RNA]
DGAT1_AND_SOAT1 -->|debate_co_mention| HK2[HK2]
DGAT1_AND_SOAT1 -->|debate_co_mention| MIRO1[MIRO1]
DGAT1_AND_SOAT1 -->|debate_co_mention| P2RY1[P2RY1]
DGAT1_AND_SOAT1 -->|debate_co_mention| P2RY1_and_P2RX7[P2RY1 and P2RX7]
SOAT1 -->|inhibits| DGAT1_AND_SOAT1
DGAT1 -->|inhibits| DGAT1_AND_SOAT1
h_7d4a24d3[h-7d4a24d3] -->|targets| DGAT1_AND_SOAT1
BMAL1[BMAL1] -->|debate_co_mention| DGAT1_AND_SOAT1
benchmark_ot_ad_answer_key_DGA[benchmark_ot_ad_answer_key:DGAT1 AND SOAT1] -->|data_in| DGAT1_AND_SOAT1| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:DGAT1 AND SOAT1 | data_in | dataset_row | 0.00 |
| Lipid Metabolism | inhibits | pathway | 0.60 |
| AND | inhibits | gene | 0.60 |
| Cholesterol | inhibits | pathway | 0.60 |
| RNA | inhibits | gene | 0.60 |
| SOAT1 | inhibits | gene | 0.60 |
| DGAT1 | inhibits | gene | 0.60 |
| HK2 | debate_co_mention | gene | 0.45 |
| MIRO1 | debate_co_mention | gene | 0.45 |
| P2RY1 | debate_co_mention | gene | 0.45 |
| P2RY1 and P2RX7 | debate_co_mention | gene | 0.45 |
| neurodegeneration | associated_with | disease | 0.40 |
| MIRO1 | co_associated_with | gene | 0.40 |
| HK2 | co_associated_with | gene | 0.40 |
| TET2 | co_associated_with | gene | 0.40 |
| PIEZO1 and KCNK2 | co_associated_with | gene | 0.40 |
| P2RY1 and P2RX7 | co_associated_with | gene | 0.40 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:DGAT1 AND SOAT1 | data_in | dataset_row | 0.00 |
| SOAT1 | inhibits | gene | 0.60 |
| DGAT1 | inhibits | gene | 0.60 |
| h-7d4a24d3 | targets | hypothesis | 0.50 |
| BMAL1 | debate_co_mention | gene | 0.45 |
| DGAT1 | debate_co_mention | gene | 0.45 |
| BMAL1 | co_associated_with | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Lipid Droplet Dynamics as Phenotype Switches | 0.666 | neurodegeneration | Astrocyte reactivity subtypes in neurode |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.741
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Proposed experiment from debate on Microglia activate astrocytes via I | falsification | Neuroinflammation | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Cytochrome Therapeutics | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Lipid Droplet-Lysosome Axis Therapeutic Testing in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Peroxisomal Dysfunction Validation in Parkinson's Disease | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,280,000 |
| Peroxisome Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Inhibition of sterol O-acyltransferase 1 blocks Zika virus infection in cell lin [PMID:39237833] | Schöbel A, Pinho Dos Reis V, Burkhard R, | Commun Biol | 2024 | 1 |
| Lipid Metabolism in Glioblastoma: From De Novo Synthesis to Storage. [PMID:36009491] | Kou Y, Geng F, Guo D | Biomedicines | 2022 | 1 |
| Lipid Stores and Lipid Metabolism Associated Gene Expression in Porcine and Bovi [PMID:32899450] | Kajdasz A, Warzych E, Derebecka N, Madej | Int J Mol Sci | 2020 | 1 |
| Inducible deletion of DGAT1 and 2 from microglia exacerbates neurodegeneration a [PMID:41546868] | ["Tabor G", "Litvinchuk A", "Chen Y", "A | Cell reports | 2026 | 0 |
| Depalmitoylation of TEAD1 facilitates lipid droplet accumulation and resistance [PMID:40889725] | ["Sun X", "Xu S", "Ni Y", "Chen R", "Dai | Free radical biology & medicin | 2025 | 0 |
| Low Dose GLP-1 Therapy Attenuates Pathological Cardiac and Hepatic Remodelling i [PMID:41256540] | ["Elbatreek M", "Li Z", "Yu X", "Gehred | bioRxiv : the preprint server | 2025 | 0 |
| AMPK protects proximal tubular epithelial cells from lysosomal dysfunction and d [PMID:39675352] | ["Pierre L", "Juszczak F", "Delmotte V", | Autophagy | 2025 | 0 |
| Inhibition of diacylglycerol O-acyltransferase 1 provides neuroprotection by inh [PMID:40375180] | ["Zeng Y", "Guo R", "Chen S", "Lin Y", " | Molecular medicine (Cambridge, | 2025 | 0 |
| Lipid droplets in Zika neuroinfection: Potential targets for intervention? [PMID:37820117] | ["Dias S", "Cunha-Fernandes T", "Soares | Memorias do Instituto Oswaldo | 2023 | 0 |
| Sulfur mustard analog 2-chloroethyl ethyl sulfide increases triglycerides by act [PMID:36106344] | ["Ye F", "Zeng Q", "Dan G", "Zhao Y", "Y | Toxicology mechanisms and meth | 2023 | 0 |
| Placental extract suppresses lipid droplet accumulation by autophagy during the [PMID:37974253] | Ando Y, Odawara E, Sakai H, Sato F, Kame | BMC research notes | 2023 | 0 |
| DGAT1 inhibitors protect pancreatic β-cells from palmitic acid-induced apoptosis [PMID:32737468] | ["Huang J", "Guo B", "Wang G", "Zeng L", | Acta pharmacologica Sinica | 2021 | 0 |
| Prime editing for functional repair in patient-derived disease models. [PMID:33097693] | ["Schene I", "Joore I", "Oka R", "Mokry | Nature communications | 2020 | 0 |
| Diacylglycerol acyltransferase 1/2 inhibition induces dysregulation of fatty aci [PMID:32786057] | ["Takemoto K", "Fukasaka Y", "Yoshimoto | Physiological reports | 2020 | 0 |
| Effect of Carotenoids from Phaeodactylum tricornutum on Palmitate-Treated HepG2 [PMID:32575640] | Mayer C, Côme M, Blanckaert V, Chini Zit | Molecules (Basel, Switzerland) | 2020 | 0 |
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning DGAT1 AND SOAT1 in their description or question text
No additional research found