gene

YME1L1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about YME1L1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

4Outgoing

11Incoming

0Experiments

0Debates

Summary

YME1L1 (YME1 Like 1) is a mitochondrial inner membrane AAA protease essential for protein quality control, mitochondrial dynamics, and neuronal survival. Mutations cause hereditary spastic paraplegia and optic atrophy.

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🧬 Gene Info

Gene Symbol	YME1L1
Full Name	YME1 Like 1 ATPase (mitochondrial inner membrane protease)
Aliases	YME1 Like 1
Chromosome	10p11.23
Protein Type	Protease
Function	is a critical mitochondrial inner membrane protease that belongs to the AAA (ATPases Associated with various cellular Activities) family of proteins.
Primary Expression	Ubiquitous (high in brain, heart, muscle, liver)
Molecular Weight	84 kDa
Amino Acids	757 aa
Pathways	Differentiation
UniProt ID	Q9Y4K0
NCBI Gene ID	10762
Ensembl ID	ENSG00000135547
OMIM	607472
GeneCards	YME1L1
Human Protein Atlas	YME1L1
Associated Diseases	neurodegeneration
Interactions	AKT, AMPK, CHCHD2, CLPP, FBXO7, HSPA9
KG Connections	15 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: YME1L1 — AlphaFold Q9Y4K0 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

YME1L1 Gene

gene · 3426 words

→

YME1L1 Protein

protein · 604 words

→

Pathway Diagram

flowchart TD
    YME1L1(["YME1L1"])
    Als["Als"]
    MITOCHONDRIA(["MITOCHONDRIA"])
    Differentiation["Differentiation"]
    AMPK(["AMPK"])
    SIRT3(["SIRT3"])
    OPA1(["OPA1"])
    SENP1(["SENP1"])
    neurodegeneration["neurodegeneration"]

    YME1L1 -->|"activates"| Als
    YME1L1 -->|"activates"| MITOCHONDRIA
    YME1L1 -->|"activates"| Differentiation
    AMPK -->|"activates"| YME1L1
    SIRT3 -->|"activates"| YME1L1
    OPA1 -->|"activates"| YME1L1
    SENP1 -->|"activates"| YME1L1
    YME1L1 -->|"implicated in"| neurodegeneration

    style YME1L1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (4)

Target	Relation	Type	Str
Als	activates	disease	0.65
MITOCHONDRIA	activates	gene	0.60
Differentiation	activates	pathway	0.60
MAPK signaling	participates_in	pathway	0.60

Incoming (11)

Source	Relation	Type	Str
CHCHD2	activates	gene	0.60
CLPP	activates	gene	0.60
FBXO7	activates	gene	0.60
HSPA9	activates	gene	0.60
HSPD1	activates	gene	0.60
AKT	activates	gene	0.60
JNK	activates	gene	0.60
SIRT3	activates	gene	0.60
OPA1	activates	gene	0.60
SENP1	activates	gene	0.60
AMPK	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning YME1L1 in their description or question text

No additional research found