gene 2,512 words KG: AXL
Contents

AXL - AXL Receptor Tyrosine Kinase

🧬 Gene Info
Gene SymbolAXL
Full NameAXL - AXL Receptor Tyrosine Kinase
AliasesPage for AXL Protein
Chromosome19q13.2
Protein TypeGene
Functionis a receptor tyrosine kinase belonging to the TAM family (TYRO3, AXL, MERTK) that plays critical roles in cell survival, migration, immune regulation, and tissue homeostasis[@graham2014].
Primary Expressionimmune cells, endothelial cells, neurons, and various peripheral tissues, where it mediates both ligand-dependent and ligand-independent signaling cas
Molecular Weight140 kDa
Amino Acids985 aa
Exons20
PathwaysNF-κB, PI3K, MAPK
UniProt IDQ9U6C5
NCBI Gene ID55768
Ensembl IDENSG00000167601
GeneCardsAXL
Human Protein AtlasAXL
Associated DiseasesAging, Alzheimer, Cancer, INFLAMMATION, Ms, NEUROINFLAMMATION
InteractionsADAM10, AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND
KG Connections199 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (5)

APOE-Dependent Autophagy Restoration
Score: 0.85
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.84
Cell-Type Specific TREM2 Upregulation in DAM Microglia
Score: 0.76
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62

Related Analyses (6)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed

See Also (7)

Astrocytes
cell · KG edge: associated_with
Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
Astrocytes
entity · KG edge: associated_with
APP Gene Dosage Reduction Therapy for Down Syndrome
idea · KG edge: associated_with
Alzheimer Indonesia
institution · KG edge: activates

Knowledge Graph (12 edges)

CXCL1 therapeutic_target AXL
CXCL10 therapeutic_target AXL
CHIT1 inhibits AXL
AXL therapeutic_target MMP12
MMP12 therapeutic_target AXL
AXL inhibits CHIT1
AXL therapeutic_target CXCL1
AXL therapeutic_target CXCL10
CXCL1 inhibits AXL
AXL inhibits CXCL10

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