gene 2,512 words KG: AXL
Contents

AXL - AXL Receptor Tyrosine Kinase

🧬 Gene Info
Gene SymbolAXL
Full NameAXL - AXL Receptor Tyrosine Kinase
AliasesPage for AXL Protein
Chromosome19q13.2
Protein TypeGene
Functionis a receptor tyrosine kinase belonging to the TAM family (TYRO3, AXL, MERTK) that plays critical roles in cell survival, migration, immune regulation, and tissue homeostasis[@graham2014].
Primary Expressionimmune cells, endothelial cells, neurons, and various peripheral tissues, where it mediates both ligand-dependent and ligand-independent signaling cas
Molecular Weight140 kDa
Amino Acids985 aa
Exons20
PathwaysNF-κB, PI3K, MAPK
UniProt IDQ9U6C5
NCBI Gene ID55768
Ensembl IDENSG00000167601
GeneCardsAXL
Human Protein AtlasAXL
Associated DiseasesAging, Alzheimer, Cancer, INFLAMMATION, Ms, NEUROINFLAMMATION
InteractionsADAM10, AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND
KG Connections202 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (1)

TAM Receptor (MERTK/AXL) Cross-Regulation
Score: 0.54

Knowledge Graph (12 edges)

CXCL1 therapeutic_target AXL
CXCL10 therapeutic_target AXL
CHIT1 inhibits AXL
AXL therapeutic_target MMP12
MMP12 therapeutic_target AXL
AXL inhibits CHIT1
AXL therapeutic_target CXCL1
AXL therapeutic_target CXCL10
CXCL1 inhibits AXL
AXL inhibits CXCL10

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