gene 2,468 words KG: TYRO3
Contents

TYRO3 - TYRO3 Receptor Tyrosine Kinase

🧬 Gene Info
Gene SymbolTYRO3
Full NameTYRO3 - TYRO3 Receptor Tyrosine Kinase
AliasesPage for TYRO3 Protein
Chromosome15q15.2
Protein TypeGene
Primary Expressionneurons, oligodendrocytes, and to a lesser extent in microglia, where it mediates cell survival, migration, and immune regulation through activation o
Molecular Weight140 kDa
Amino Acids903 aa
Exons22
PathwaysNF-κB, PI3K, MAPK
UniProt IDQ06418
NCBI Gene ID7304
Ensembl IDENSG00000092470
GeneCardsTYRO3
Human Protein AtlasTYRO3
Associated DiseasesAging, Diabetes, Ferroptosis, neuroinflammation
SciDEX HypothesesTYRO3-STAT1 Axis to Preserve Parvalbumin Interneur
KG Connections18 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (7)

APOE-Dependent Autophagy Restoration
Score: 0.88
Circadian Glymphatic Entrainment via Targeted Orexin Recepto
Score: 0.86
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.82
Magnetosonic-Triggered Transferrin Receptor Clustering
Score: 0.72
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Piezoelectric Nanochannel BBB Disruption
Score: 0.52

Related Analyses (6)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Mechanistic role of APOE in neurodegeneration
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · completed

See Also (11)

Neurodegeneration
disease · KG edge: implicated_in
STAT3 (Redirect)
redirect · KG edge: associated_with
Ferroptosis Validation in Parkinson's Disease
experiment · KG edge: associated_with
Complement System Dysregulation in Neurodegeneration -
gap · KG edge: associated_with
ARNTL Gene — Aryl Hydrocarbon Receptor Nuclear Transloc
gene · KG edge: associated_with

Knowledge Graph (12 edges)

STAT3 associated_with TYRO3
KDM5A associated_with TYRO3
TYRO3 associated_with SREBF1
TYRO3 associated_with CAMKK2
TYRO3 associated_with CDKN1A
TYRO3 associated_with CTSB
TYRO3 associated_with ARNTL
h-315367de targets TYRO3
FURIN associated_with TYRO3
COMPLEMENT associated_with TYRO3

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