| Gene Symbol | ROR2PROTEIN |
| Protein Type | Receptor |
| Function | is a member of the receptor tyrosine kinase-like orphan receptor (ROR) family that functions as a receptor for Wnt ligands, primarily Wnt5a. |
| Primary Expression | adult tissues including the brain |
| Subcellular Localization | </span><span class="infobox-value">Plasma membrane, Primary cilia</span></div> |
| Molecular Weight | 110 kDa |
| Amino Acids | 943 aa |
| GeneCards | ROR2PROTEIN |
| Human Protein Atlas | ROR2PROTEIN |
| CRD (Cysteine-rich Domain) | The extracellular CRD directly binds Wnt5a and other Wnt ligands. Unlike Frizzled receptors, ROR2 CRD shows distinct binding specificity for non-canonical Wnts. |
| Kringle Domains | These domains mediate protein-protein interactions and may contribute to receptor oligomerization. |
| Inactive Kinase Domain | ROR2 possesses a kinase domain with mutations that impair catalytic activity. Instead, it functions as a scaffoldsome assembly platform, recruiting downstream signaling proteins. |
| Primary Cilia Localization | ROR2 localizes to primary cilia, where it participates in cilia-dependent signaling pathways. |
| Glycosylation | Heavily N-glycosylated in the extracellular domain |
| Phosphorylation | Several tyrosine and serine/threonine phosphorylation sites |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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