gene 547 words KG: MET
Contents

MET - MET Proto-Oncogene, Receptor Tyrosine Kinase

🧬 Gene Info
Gene SymbolMET
AliasesPage for MET, c-Met
Chromosome7q31.2
Protein TypeReceptor
Functionis a receptor tyrosine kinase (RTK) that plays crucial roles in embryonic development, tissue regeneration, and adult tissue homeostasis.
Molecular Weight140 kDa
Amino Acids1390 aa
Exons21
PathwaysKey Effectors
GeneCardsMET
Human Protein AtlasMET
Associated DiseasesAD, Aging, ALI, Als, Alzheimer, AMI
Known Drugs/Compoundsmetformin, PLB-1001, resveratrol
InteractionsAKT, ALS, ALZHEIMER, ALZHEIMER'S DISEASE, AMPK, AMYLOID
KG Connections644 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

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Knowledge Graph

Related Hypotheses (23)

The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction
Score: 0.65
The Glial Ketone Metabolic Shunt Hypothesis
Score: 0.61
Brain Insulin Resistance with Glucose Transporter Dysfunctio
Score: 0.60
Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91
AMPK hypersensitivity in astrocytes creates enhanced mitocho
Score: 0.81

Related Analyses (11)

Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived

Related Experiments (1)

AD Amyloid-Resilient Phenotype Study — Why Some amyloid-Posi
clinical · proposed · Score: 0.40

See Also (15)

Exosomal Biomarkers in Neurodegeneration
biomarker · Pages share 7 hypotheses
Exosomal miR-155 in Neurodegeneration
biomarker · Pages share 7 hypotheses
IL-6 (Interleukin-6) in Neurodegeneration
biomarker · Pages share 7 hypotheses
Liquid Biopsy in Neurodegeneration
biomarker · Pages share 7 hypotheses
Metabolomic Biomarkers in Neurodegeneration
biomarker · Pages share 7 hypotheses

Knowledge Graph (12 edges)

IDH1 therapeutic_target MET
VEGFA therapeutic_target MET
MDM4 therapeutic_target MET
APOB inhibits MET
SF3B1 therapeutic_target MET
MET therapeutic_target SMARCA4
MET therapeutic_target TERT
MET therapeutic_target JUN
MET therapeutic_target EEF1A1
MET therapeutic_target MCL1

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