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gene 4,033 words KG: PEN2
Contents

PEN2 Gene

🧬 Gene Info
Gene SymbolPSENEN
AliasesPresenilin Enhancer 2
Chromosome19q13.12
Protein FamilyPEN-2 family (γ-secretase complex)
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionEndoplasmic reticulum, Golgi apparatus, plasma membrane
Molecular Weight12 kDa
Amino Acids101 aa
PathwaysAngiogenesis
UniProt IDQ9NQ75
GeneCardsPSENEN
Human Protein AtlasPSENEN
Associated DiseasesAD, Als, Alzheimer, Alzheimer's disease, AMI
InteractionsA2M, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, APH1B, APOE
KG Connections94 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (23)

APOE-Dependent Autophagy Restoration
Score: 0.88Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79Competitive APOE4 Domain Stabilization Peptides
Score: 0.78APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76APOE Isoform Expression Across Glial Subtypes
Score: 0.74Senescent Cell Mitochondrial DNA Release
Score: 0.74Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.74PARP1 Inhibition Therapy
Score: 0.74CYP46A1 Overexpression Gene Therapy
Score: 0.73TFAM overexpression creates mitochondrial donor-recipient gr
Score: 0.73Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72Mitochondrial Transfer Pathway Enhancement
Score: 0.70Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69Palmitoylation-Targeted BACE1 Trafficking Disruptors
Score: 0.69CX43 hemichannel engineering enables size-selective mitochon
Score: 0.69RAB27A-dependent extracellular vesicle engineering for mitoc
Score: 0.67Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67GAP43-mediated tunneling nanotube stabilization enhances neu
Score: 0.67Mitochondrial RNA Granule Rescue Pathway
Score: 0.66
pg 1/2Next →

Related Analyses (4)

4R-tau strain-specific spreading patterns in PSP vs CBD
neurodegeneration · archivedNeuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archivedLipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completedCircuit-level neural dynamics in neurodegeneration
neuroscience · archived

See Also (15)

Apoptosis in Neurodegeneration
entity · KG edge: interacts_withAmyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: interacts_withDNA Damage Repair Deficiency Validation Study in Parkin
experiment · KG edge: interacts_withA2M Gene
gene · KG edge: interacts_withANG — Angiogenin
gene · KG edge: associated_with

Knowledge Graph (12 edges)

NCSTN interacts_with PEN2
FAS interacts_with PEN2
TNF interacts_with PEN2
LMNA interacts_with PEN2
APH1B interacts_with PEN2
APOE interacts_with PEN2
IL6 interacts_with PEN2
SREBF1 interacts_with PEN2
PSEN2 interacts_with PEN2
A2M interacts_with PEN2

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