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gene 1,571 words KG: NRF2
Contents

NRF2 Gene

🧬 Gene Info
Gene SymbolNRF2
Chromosome2q31.2
Protein FamilyCap'n'Collar (CNC) bZIP transcription factor
FunctionBasal state: Keap1 homodimer binds NRF2 via the DLG and ETGE motifs, serving as a substrate adapter for the Cul3-RING ubiquitin E3 ligase complex.
Molecular Weight68 kDa
Amino Acids605 aa
PathwaysAkt, Apoptosis, Autophagy, Cell Cycle, Chaperone
GeneCardsNRF2
Human Protein AtlasNRF2
Associated Diseasesaging, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds4-octyl itaconate, 4OI, ALGERNON2, Alpha-Tocopherol, Artesunate, ATORVASTATIN
InteractionsABCG2, ACETYLCHOLINE, ACHE, ACOD1, ACSL4, Actin
KG Connections3658 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

No AI portrait yet

Knowledge Graph

Related Hypotheses (30)

ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro
Score: 0.85CYP46A1 Overexpression Gene Therapy
Score: 0.92Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.91Transcriptional Autophagy-Lysosome Coupling
Score: 0.88Gamma entrainment therapy to restore hippocampal-cortical sy
Score: 0.85

Related Analyses (25)

CRISPR-based therapeutic approaches for neurodegenerative di
neurodegeneration · completedSelective vulnerability of entorhinal cortex layer II neuron
neurodegeneration · archivedTDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archivedAstrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archivedBlood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived

Related Experiments (6)

Acteoside treatment in LPS-induced SALI mouse model
validation · proposed · Score: 0.90Nrf2 inhibitor ML385 mechanism validation experiment
exploratory · proposed · Score: 0.85Acteoside effects on RAW264.7 macrophage cells
exploratory · proposed · Score: 0.85Cytochrome Therapeutics
clinical · proposed · Score: 0.40Proposed experiment from debate on Perivascular spaces and g
falsification · proposed · Score: 0.40

See Also (6)

acetylcholine
general · KG edge: co_discussedABCG2 (BCRP) - ATP Binding Cassette Subfamily G Member
gene · KG edge: activatesACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Memb
gene · KG edge: associated_withACTB Gene
gene · KG edge: causesADAM10 — A Disintegrin And Metalloproteinase Domain 10
gene · KG edge: regulates

Knowledge Graph (12 edges)

AKT activates NRF2
NRF2 interacts_with KEAP1
REDOX_SIGNALING regulates NRF2
NRF2 inhibits KEAP1
NRF2 regulates HMOX1
NRF2 regulates GCLC
NRF2 regulates GCLM
NRF2 regulates NQO1
NRF2 regulates TXNRD1
KEAP1 regulates NRF2

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