concept

NITRIC OXIDE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NITRIC OXIDE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

121Connections

0Hypotheses

0Analyses

29Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	NITRIC OXIDE
Key Genes/Proteins	AKT, CLU, GFAP, JNK
Related Diseases	AGING, INFLAMMATION, NEURODEGENERATION, OXIDATIVE STRESS

Pathway Diagram

graph TD
    NITRIC_OXIDE[NITRIC OXIDE]
    NITRIC_OXIDE -->|inhibits| Endothelial_Dysfunction[Endothelial Dysfunction]
    NITRIC_OXIDE -->|released_by| endothelial_cells[endothelial cells]
    NITRIC_OXIDE -->|modulates| Vascular_Remodelling[Vascular Remodelling]
    NITRIC_OXIDE -->|mediates| Antibacterial_Response[Antibacterial Response]
    NITRIC_OXIDE -->|mediates| Bacteria[Bacteria]
    NITRIC_OXIDE -->|released_by| astrocytes[astrocytes]
    NITRIC_OXIDE -->|released_by| macrophages[macrophages]
    NITRIC_OXIDE -->|phosphorylates| TAU[TAU]
    Asymmetric_Dimethyl_Arginine[Asymmetric Dimethyl Arginine] -->|inhibits| NITRIC_OXIDE
    SODs[SODs] -.protects against.-> NITRIC_OXIDE
    CREB[CREB] -->|activates| NITRIC_OXIDE
    ROS[ROS] -->|activates| NITRIC_OXIDE
    CLU[CLU] -->|inhibits| NITRIC_OXIDE
    AKT[AKT] -->|interacts| NITRIC_OXIDE
    TLR4[TLR4] -->|causes| NITRIC_OXIDE
    MICROGLIA[MICROGLIA] -->|produces| NITRIC_OXIDE

Outgoing (29)

Target	Relation	Type	Str
Endothelial Dysfunction	inhibits	process	0.90
endothelial cells	released_by	cell_type	0.90
Bacteria	mediates	organism	0.85
Endothelial Dysfunction	protects_against	phenotype	0.85
Antibacterial Response	mediates	process	0.85
Vascular Remodelling	modulates	process	0.85
astrocytes	released_by	cell_type	0.70
macrophages	released_by	cell_type	0.70
ASTROCYTES	causes	cell_type	0.65
ASTROCYTES	treats	cell_type	0.65
OXIDATIVE STRESS	activates	phenotype	0.65
OXIDATIVE STRESS	interacts_with	phenotype	0.65
TAU	phosphorylates	protein	0.65
GFAP	activates	gene	0.65
CHOROID PLEXUS	inhibits	brain_region	0.65
NEURODEGENERATION	causes	disease	0.65
TAU	exacerbates	protein	0.65
JNK	activates	gene	0.65
INFLAMMATION	activates	phenotype	0.65
OXIDATIVE STRESS	inhibits	phenotype	0.65
microglia	released_by	cell_type	0.60
neural stem cells	released_by	cell_type	0.60
blood-brain barrier	active_in	brain_region	0.60
ASTROCYTES	participates_in	cell_type	0.55
BRAINSTEM	associated_with	brain_region	0.45
CORTEX	associated_with	brain_region	0.45
PONS	associated_with	brain_region	0.45
RAPAMYCIN	associated_with	drug	0.45
METFORMIN	associated_with	drug	0.45

Incoming (92)

Source	Relation	Type	Str
Asymmetric Dimethyl Arginine	inhibits	compound	0.85
SODs	protects_against	protein	0.80
ROS	activates	gene	0.70
CREB	activates	gene	0.70
TLR4	causes	gene	0.65
CLU	inhibits	gene	0.65
AKT	interacts_with	gene	0.65
AKT	activates	gene	0.65
AGING	interacts_with	phenotype	0.65
AKT	regulates	gene	0.65
METFORMIN	treats	drug	0.65
MICROGLIA	produces	cell_type	0.65
SIRT1	regulates	gene	0.60
TP53	regulates	gene	0.60
FOXO1	regulates	gene	0.60
MTOR	regulates	gene	0.60
C1Q	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
LC3	regulates	gene	0.60
LC3	interacts_with	gene	0.60
migraine	disrupts	disease	0.60
neurodegeneration	disrupts	disease	0.60
PRMT1	inhibits	gene	0.60
PRMT1	regulates	gene	0.60
CAV1	activates	gene	0.60
MMP2	activates	gene	0.60
MMP9	activates	gene	0.60
GLP1R	regulates	gene	0.60
ULK1	regulates	gene	0.60
BECN1	regulates	gene	0.60
PLIN2	regulates	gene	0.60
LAMP2	regulates	gene	0.60
NFE2L2	regulates	gene	0.60
VEGF	activates	gene	0.60
PI3K	activates	gene	0.60
VEGF	interacts_with	gene	0.60
PI3K	interacts_with	gene	0.60
KCNK2	expressed_in	gene	0.60
GLP1R	activates	gene	0.60
SIRT1	activates	gene	0.60
obesity	disrupts	disease	0.60
TNF	treats	gene	0.60
ANXA1	inhibits	gene	0.60
ANXA1	treats	gene	0.60
spinal muscular atrophy	disrupts	disease	0.60
MAP1LC3	activates	gene	0.60
RAS	activates	gene	0.60
MTORC1	regulates	gene	0.60
AMPK	regulates	gene	0.60
CREB	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning NITRIC OXIDE in their description or question text

No additional research found