| Gene Symbol | NCF4 |
| Full Name | Neutrophil Cytosolic Factor 4 (p40^phox^) |
| Protein Type | Enzyme |
| Function | is a regulatory subunit of the NADPH oxidase (NOX2) complex that plays a critical role in generating reactive oxygen species (ROS) in phagocytic cells. |
| Primary Expression | microglia—the resident immune cells of the brain—where it contributes to neuroinflammatory processes that are central to neurodegenerative disease pat |
| Amino Acids | 80 aa |
| UniProt ID | Q9UHI5 |
| NCBI Gene ID | 3074 |
| Ensembl ID | ENSG00000100129 |
| OMIM | 604467 |
| GeneCards | NCF4 |
| Human Protein Atlas | NCF4 |
| PX Domain (1-80 aa) | Phosphoinositide-binding module that targets p40^phox^ to cellular membranes and phagocytic vesicles |
| SH3 Domain (120-180 aa) | Proline-rich region that mediates protein-protein interactions with other phox components |
| PCD Domain (200-280 aa) | Protein interaction domain |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
No AI portrait yet
No comments yet. Be the first to comment!