Contents

NPC1 Gene

🧬 Gene Info

Gene Symbol	NPC1
Chromosome	18q11.2
Protein Type	Transporter
Function	It functions as a key transporter in the late endosomal/lysosomal (LE/LY) system[4]
Subcellular Localization	the limiting membrane of late endosomes and lysosomes. It functions as a key transporter in the **late endosomal/lysosom
Pathways	Wnt signaling pathway
GeneCards	NPC1
Human Protein Atlas	NPC1
Associated Diseases	Als, disease, frontotemporal dementia, Ms, neurodegeneration
Interactions	ABCA1, AGING, ALPHA-SYNUCLEIN, AND, APOE3, APOE4
SciDEX Hypotheses	APOE4-driven lysosome-to-ER cholesterol transport
KG Connections	240 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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Knowledge Graph

NPC1 interacts_with STING1

NPC1 regulates STING1

CGAS interacts_with NPC1

NPC1 interacts_with STING

STING interacts_with NPC1

CGAS activates NPC1

NPC1 interacts_with CD63

SCARB2 associated_with NPC1

UBE2D1 associated_with NPC1