Are

Multiple NDDs converge on autophagy-lysosome dysfunction. Are there universal th

closed · Rounds: 4 · Score: 0.90 · 2026-04-06

SPMs (resolvins, protectins, maresins) from omega-3s may promote inflammation re

closed · Rounds: 4 · Score: 0.83 · 2026-04-06

ATAC-seq accessibility separates causal from compensatory states in: Are age-rel

Score: 0.738 · neurodegeneration · 2026-04-26

A longitudinal biomarker panel centered on ATAC-seq accessibility can distinguish harmful mechanisms from protective ada

Endosomal trafficking defects are the common upstream lesion linking APP process

Score: 0.730 · neurodegeneration · 2026-04-25

AD-risk trafficking defects in SORL1/BIN1/PICALM/retromer may generate parallel early outputs: amyloidogenic APP sorting

protective chromatin remodeling defines the therapeutic window for: Are age-rela

Score: 0.720 · neurodegeneration · 2026-04-26

The same signal may be beneficial early and damaging late. Testing protective chromatin remodeling with single-cell meth

protective chromatin remodeling defines the therapeutic window for: Are DNA meth

Score: 0.720 · neurodegeneration · 2026-04-26

The same signal may be beneficial early and damaging late. Testing protective chromatin remodeling with single-cell meth

Microglial TREM2 state determines whether C1q-tagged substrates are cleared adap

Score: 0.670 · neurodegeneration · 2026-04-25

This hypothesis reconciles conflicting C1q phenotypes by placing receiver-cell state downstream of a common upstream C1q

Vascular mural cell degeneration precedes and exacerbates parenchymal pathology

Score: 0.637 · Alzheimer's disease · 2026-04-04

## Mechanistic Overview Vascular mural cell degeneration precedes and exacerbates parenchymal pathology starts from the

LYTL and JIP4-dependent lysosomal remodeling may show mutant-selective amplifica

Score: 0.580 · neurodegeneration · 2026-04-24

A more mechanistic but less translationally mature possibility is that G2019S does not strongly alter total phospho-Rab

Circadian-Gated Maresin Biosynthesis Amplification

Score: 0.557 · neurodegeneration · 2026-04-02

## Mechanistic Overview Circadian-Gated Maresin Biosynthesis Amplification starts from the claim that modulating ALOX12

Disease-Elevated CHI3L1/CHIT1 Chitinases Are Biomarkers and Partial Compensators

Score: 0.500 · ALS · 2026-04-26

Poorly lipidated APOE4 particles are preferentially routed through LDLR/LRP1 int

Score: 0.340 · molecular biology · 2026-04-24

This is the weakest mechanistic proposal. It attempts to connect extracellular apoE particle quality to intracellular ER

Rare TREM2-TYROBP pathway variants complement standard PRS by identifying microg

Score: 0.000 · Late-onset Alzheimer's disease · 2026-04-26

We hypothesize that rare loss-of-function variants in microglial-expressed genes within the TREM2-TYROBP signaling casca

Convergent NF-κB enhancers across diverse priming stimuli share therapeutic vuln

Score: 0.000 · Alzheimer's disease · 2026-04-26

Despite different initial triggers (LPS, β-amyloid, aging), primed microglia may converge on a common 'epigenetic primin