gene 1,010 words KG: LRP6
Contents

LRP6 Gene

🧬 Gene Info
Gene SymbolLRP6
Chromosome12p13.2
Protein TypeReceptor
FunctionWnt ligand binds to LRP6 extracellular domain
Molecular Weight180 kDa
Pathwayssignaling: **Canonical Pathway Activation:**, Wnt, Wnt signaling
UniProt IDO75151
NCBI Gene ID4040
Ensembl IDENSG00000170054
GeneCardsLRP6
Human Protein AtlasLRP6
Associated DiseasesALS
InteractionsAKT, AKT1, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND
KG Connections102 knowledge graph edges
DatabasesGeneCardsHPASTRING

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Knowledge Graph

Related Hypotheses (14)

CYP46A1 Overexpression Gene Therapy
Score: 0.95
Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna
Score: 0.82
Selective APOE4 Degradation via Proteolysis Targeting Chimer
Score: 0.79
Competitive APOE4 Domain Stabilization Peptides
Score: 0.78
APOE4 Allosteric Rescue via Small Molecule Chaperones
Score: 0.76
Targeted APOE4-to-APOE3 Base Editing Therapy
Score: 0.76
APOE Isoform Expression Across Glial Subtypes
Score: 0.74
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73
Interfacial Lipid Mimetics to Disrupt Domain Interaction
Score: 0.72
Sleep Spindle-Synaptic Plasticity Enhancement
Score: 0.72
Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides
Score: 0.72
Perforant Path Presynaptic Terminal Protection Strategy
Score: 0.70
Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th
Score: 0.69
Digital Twin-Guided Metabolic Reprogramming
Score: 0.55

Related Analyses (6)

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas
neurodegeneration · completed
Blood-brain barrier transport mechanisms for antibody therap
neurodegeneration · archived
Neuroinflammation resolution mechanisms and pro-resolving me
neurodegeneration · archived
Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Sleep disruption as cause and consequence of neurodegenerati
neurodegeneration · archived

See Also (9)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
AKT1 Gene
gene · KG edge: activates
APOB Gene
gene · KG edge: contributes_to
CTSD — Cathepsin D
gene · KG edge: inhibits
DVL1 Gene
gene · KG edge: interacts_with

Knowledge Graph (12 edges)

LRP5 associated_with LRP6
LRP6 associated_with LDLR
LRP6 protects_against cardiac hypertrophy
LRP6 interacts_with HSP90α
LRP6 interacts_with CTSD
LRP6 activates CTSD
LRP6 associated_with LRP5
CTSD inhibits LRP6
DVL1 interacts_with LRP6
LRP6 interacts_with LRRK2

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