concept

LOXL1-4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LOXL1-4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

72Connections

0Hypotheses

1Analyses

39Outgoing

33Incoming

0Experiments

1Debates

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💡 Concept Info

Name	LOXL1-4
Key Genes/Proteins	AND, AQP1, AQP4, CANCER, GENES, GJA1
Related Diseases	Als, ALS, cancer, Cancer, Glioma
Related Pathways	Immune Response

Pathway Diagram

graph TD
    LOXL1_4["LOXL1-4"]
    style LOXL1_4 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    LOXL1_4 -->|"regulates"| Cancer["Cancer"]
    LOXL1_4 -->|"target for"| Ms["Ms"]
    LOXL1_4 -->|"target for"| Tumor["Tumor"]
    LOXL1_4 -->|"regulates"| Als["Als"]
    LOXL1_4 -->|"target for"| Glioma["Glioma"]
    LOXL1_4 -->|"regulates"| ALS["ALS"]
    LOXL1_4 -->|"interacts"| LOX([LOX])
    LOXL1_4 -->|"regulates"| Lipid_Metabolism["Lipid Metabolism"]
    h_82922df8["h-82922df8"] -->|"targets"| LOXL1_4
    LOX -->|"interacts"| LOXL1_4
    GENES([GENES]) -->|"target for"| LOXL1_4
    LOX_LOXL1_4([LOX/LOXL1-4]) -->|"regulates"| LOXL1_4
    CANCER([CANCER]) -->|"regulates"| LOXL1_4
    LOXL3([LOXL3]) -->|"target for"| LOXL1_4
    LOXL1([LOXL1]) -->|"regulates"| LOXL1_4

Outgoing (39)

Target	Relation	Type	Str
Glioma	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Cancer	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Tumor	expressed_in	disease	0.65
ALS	regulates	disease	0.65
LOX	interacts_with	gene	0.64
neurodegeneration	associated_with	disease	0.64
Lipid Metabolism	regulates	pathway	0.60
Immune Response	regulates	pathway	0.60
LOX/LOXL1-4	stabilizes	gene	0.60
Immune Response	associated_with	pathway	0.60
Lipid Metabolism	associated_with	pathway	0.60
CANCER	regulates	gene	0.60
LOX	stabilizes	gene	0.60
RNA	expressed_in	gene	0.60
AND	regulates	gene	0.60
LOXL3	expressed_in	gene	0.60
LOXL1	regulates	gene	0.60
GENES	expressed_in	gene	0.60
LR.LOXL3	regulates	gene	0.60
LOXL1	stabilizes	gene	0.60
LOXL3	stabilizes	gene	0.60
LOXL2	expressed_in	gene	0.60
LOX	regulates	gene	0.60
LOX/LOXL1-4	regulates	gene	0.60
T Cell	expressed_in	cell_type	0.55
Macrophage	expressed_in	cell_type	0.55
OXIDATIVE STRESS	involved_in	pathway	0.55
Nrf2 / oxidative stress response	participates_in	pathway	0.50
GJA1	co_discussed	gene	0.40
KCNK2	co_discussed	gene	0.40
HCRTR1	co_discussed	gene	0.40
AQP4	co_discussed	gene	0.40
LOX	co_discussed	gene	0.40
SDC1	co_discussed	gene	0.40
PDGFRB	co_discussed	gene	0.40

Incoming (33)

Source	Relation	Type	Str
h-82922df8	targets	hypothesis	0.90
LOX	interacts_with	gene	0.64
LOXL1	regulates	gene	0.60
AND	regulates	gene	0.60
LOXL2	therapeutic_target	gene	0.60
LOXL3	associated_with	gene	0.60
LOXL1	associated_with	gene	0.60
LR.LOXL3	implicated_in	gene	0.60
AND	implicated_in	gene	0.60
LOX/LOXL1-4	associated_with	entity	0.60
LOXL3	therapeutic_target	gene	0.60
LOX/LOXL1-4	stabilizes	gene	0.60
LOX	regulates	gene	0.60
LOX	associated_with	gene	0.60
LOXL3	expressed_in	gene	0.60
LOXL1	stabilizes	gene	0.60
LR.LOXL3	regulates	gene	0.60
LOXL3	stabilizes	gene	0.60
LOX/LOXL1-4	regulates	gene	0.60
LOX	stabilizes	gene	0.60
GENES	therapeutic_target	gene	0.60
GENES	expressed_in	gene	0.60
CANCER	regulates	gene	0.60
cancer	regulates	disease	0.50
PDGFRB	co_discussed	gene	0.40
SDC1	co_discussed	gene	0.40
AQP4	co_discussed	gene	0.40
HCRTR1	co_discussed	gene	0.40
AQP1	co_discussed	gene	0.40
KCNK2	co_discussed	gene	0.40
GJA1	co_discussed	gene	0.40
HCRTR2	co_discussed	gene	0.40
LOX	co_discussed	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Perivascular spaces and glymphatic clearance failure in AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.841

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Perivascular spaces and glymphatic clearance failure in AD

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

Related Research

Hypotheses and analyses mentioning LOXL1-4 in their description or question text

No additional research found