Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about OLFML3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | OLFML3 |
| Key Genes/Proteins | CLOCK, GBM, LOX, Nf-Κb, PATZ1, PD1 |
| Related Diseases | glioblastoma |
| Related Pathways | NF-kB signaling, NF-κB-PATZ1 |
graph TD
OLFML3[OLFML3]
OLFML3 -->|expressed in| Microglia[Microglia]
OLFML3 -->|regulates| Microglia_Infiltration[Microglia Infiltration]
OLFML3 -->|activates| microglia_infiltration[microglia infiltration]
OLFML3 -->|expressed in| microglia[microglia]
OLFML3 -->|activates| PTEN[PTEN]
OLFML3 -->|inhibits| PD1[PD1]
OLFML3 -->|activates| PATZ1[PATZ1]
OLFML3 -->|expressed in| macrophages[macrophages]
NF__B_PATZ1[NF-κB-PATZ1] -->|upregulates| OLFML3
PATZ1 -->|regulates| OLFML3
Nf__b[Nf-Κb] -->|upregulates| OLFML3
LOX[LOX] -->|regulates| OLFML3
CLOCK[CLOCK] -->|regulates| OLFML3
GBM[GBM] -->|activates| OLFML3| Target | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:OLFML3 | data_in | dataset_row | 0.00 |
| Microglia | expressed_in | cell_type | 0.95 |
| Microglia Infiltration | regulates | process | 0.90 |
| Microglia Infiltration | mediates | process | 0.85 |
| microglia infiltration | activates | process | 0.70 |
| microglia | expressed_in | cell_type | 0.70 |
| microglia | associated_with | cell_type | 0.70 |
| PTEN | activates | gene | 0.60 |
| PD1 | inhibits | gene | 0.60 |
| PTEN | inhibits | gene | 0.60 |
| PATZ1 | activates | gene | 0.60 |
| NF-kB signaling | participates_in | pathway | 0.60 |
| macrophages | expressed_in | cell_type | 0.60 |
| glioblastoma | inhibits | disease | 0.60 |
| glioblastoma | activates | disease | 0.60 |
| glioblastoma | associated_with | disease | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| benchmark_ot_ad_answer_key:OLFML3 | data_in | dataset_row | 0.00 |
| NF-κB-PATZ1 | upregulates | pathway | 0.90 |
| Nf-Κb | upregulates | protein | 0.85 |
| PATZ1 | regulates | gene | 0.85 |
| NF-κB-PATZ1 | activates | pathway | 0.70 |
| CLOCK | regulates | protein | 0.70 |
| LOX | regulates | protein | 0.70 |
| LOX | activates | gene | 0.60 |
| CLOCK | inhibits | gene | 0.60 |
| GBM | inhibits | gene | 0.60 |
| LOX | inhibits | gene | 0.60 |
| GBM | associated_with | gene | 0.60 |
| LOX | associated_with | gene | 0.60 |
| GBM | activates | gene | 0.60 |
| PTEN | inhibits | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning OLFML3 in their description or question text
No additional research found