Contents

LATE (Limbic-Predominant Age-Related TDP-43 Encephalopathy)

Disease Info

TDP-43 Pathology	Phosphorylated, ubiquitinated, and truncated TDP-43 inclusions
Limbic Predominance	Primary involvement of amygdala, hippocampus, and entorhinal cortex
Age Association	Typically onset after age 80
Clinical Phenotype	Amnestic syndrome resembling AD but with distinct progression
Age 70-79	Approximately 5-10% prevalence
Age 80-89	Approximately 15-20% prevalence
Age 90+	Up to 25-30% prevalence in some cohorts
Databases	OMIM Orphanet ClinicalTrials PubMed

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