Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NETRIN-1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | NETRIN |
| Subcellular Localization | ** | Extracellular, secreted | |
| Molecular Weight | 70 kDa |
| Pathways | PI3K |
| GeneCards | NETRIN |
| Human Protein Atlas | NETRIN |
| N-terminal domain | Contains the laminin VI domain crucial for receptor binding |
| Central domain | Laminin-like domains (Laminin domain V) |
| C-terminal domain | Heparin-binding region for extracellular matrix association |
| Attractive signaling | Through DCC/neogenin receptors |
| Repulsive signaling | Through UNC5 family receptors |
| Associated Diseases | Endometrial Cancer, Cancer |
| Interactions | UNC5B |
| KG Connections | 15 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
NETRIN_1["NETRIN-1"]
NETRIN_1 -->|"inhibits"| Tumour_Growth["Tumour Growth"]
NETRIN_1 -->|"regulates"| EMT["EMT"]
NETRIN_1 -->|"binds"| UNC5B["UNC5B"]
NETRIN_1 -->|"inhibits"| cancer["cancer"]
NETRIN_1 -->|"activates"| CARCINOMA["CARCINOMA"]
NETRIN_1 -->|"activates"| EXOSOMES["EXOSOMES"]
NETRIN_1 -->|"activates"| Endothelial_Cell["Endothelial Cell"]
Pharmacological_Targeting["Pharmacological Targeting"] -->|"targets"| NETRIN_1
UNC5B -->|"binds"| NETRIN_1
ADORA2B["ADORA2B"] -->|"binds"| NETRIN_1
late["late"] -->|"activates"| NETRIN_1
NTN1["NTN1"] -->|"regulates"| NETRIN_1| Target | Relation | Type | Str |
|---|---|---|---|
| Tumour Growth | inhibits | phenotype | 0.95 |
| EMT | regulates | process | 0.95 |
| UNC5B | binds | gene | 0.90 |
| Endometrial Cancer | associated_with | disease | 0.90 |
| Cancer | associated_with | disease | 0.90 |
| Endothelial Cells | activates | cell | 0.90 |
| Endometrial Carcinoma | associated_with | disease | 0.90 |
| endothelial cell exosomes | engineers | cellular_component | 0.80 |
| EMT | inhibits | process | 0.80 |
| tumor growth | inhibits | process | 0.80 |
| CARCINOMA | activates | disease | 0.50 |
| EXOSOMES | activates | concept | 0.50 |
| Endothelial Cell | activates | cell_type | 0.50 |
| ENDOTHELIAL | activates | concept | 0.50 |
| cancer | inhibits | disease | 0.50 |
| cancer | activates | disease | 0.50 |
| TUMOR | activates | disease | 0.50 |
| Hippocampus | activates | entity | 0.50 |
| GLUTAMATE | activates | concept | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Netrin-1 Gradient Restoration | 0.595 | neurodegeneration | 4R-tau strain-specific spreading pattern |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| Multi-omics analysis of NP137 mechanism in patient biopsies | exploratory | endometrial carcinoma | 0.900 | 0.00 | human patient biopsies | proposed | N/A |
| Anti-netrin-1 antibody efficacy in EC mouse model | validation | endometrial carcinoma | 0.900 | 0.00 | endometrial carcinoma mouse mo | proposed | N/A |
| NP137 antibody treatment effects on EMT and metastasis in mouse SCC | validation | Skin squamous cell carcinoma | 0.900 | 0.00 | Primary mouse model | proposed | N/A |
| NP137 treatment of A549 human cancer cell xenografts | validation | Cancer | 0.850 | 0.00 | A549 human cancer cell xenogra | proposed | N/A |
| Combination therapy with NP137 and carboplatin-paclitaxel | validation | endometrial carcinoma | 0.850 | 0.00 | endometrial carcinoma mouse mo | proposed | N/A |
| Netrin-1 and UNC5B knockdown effects on EMT in vitro | exploratory | Cancer | 0.850 | 0.00 | EPCAM+ tumor cells in vitro | proposed | N/A |
| Netrin-1 expression in primary mouse skin SCC model with spontaneous E | validation | Skin squamous cell carcinoma | 0.800 | 0.00 | Primary mouse model | proposed | N/A |
| Netrin-1 expression analysis in human endometrial carcinomas | exploratory | endometrial carcinoma | 0.800 | 0.00 | human endometrial carcinoma ti | proposed | N/A |
| Neural Stem Cell Therapy for Alzheimer's Disease | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Proteomic landscape of Alzheimer's disease: emerging technologies, advances and [PMID:40660303] | Yarbro JM, Shrestha HK, Wang Z, Zhang X, | Mol Neurodegener | 2025 | 1 |
| Netrin-1-engineered endothelial cell exosomes induce the formation of pre-regene [PMID:38941462] | Huang J, Li J, Li S, Yang X, Huo N, Chen | Sci Adv | 2024 | 1 |
| Pharmacological targeting of netrin-1 inhibits EMT in cancer. [PMID:37532929] | Lengrand J, Pastushenko I, Vanuytven S, | Nature | 2023 | 1 |
| Dissecting Detergent-Insoluble Proteome in Alzheimer's Disease by TMTc-Corrected [PMID:37356496] | Zaman M, Fu Y, Chen PC, Sun H, Yang S, W | Mol Cell Proteomics | 2023 | 1 |
| Netrin-1 blockade inhibits tumour growth and EMT features in endometrial cancer. [PMID:37532934] | Cassier PA, Navaridas R, Bellina M, Rama | Nature | 2023 | 1 |
| Interplay between Netrin-1 and Norrin controls arteriovenous zonation of blood-r [PMID:39693351] | Furtado J, Geraldo LH, Leser FS, Bartkow | Proceedings of the National Ac | 2024 | 0 |
| Microskeletal stiffness promotes aortic aneurysm by sustaining pathological vasc [PMID:35082286] | Qian W, Hadi T, Silvestro M, Ma X, River | Nature communications | 2022 | 0 |
| Neurog2 Acts as a Classical Proneural Gene in the Ventromedial Hypothalamus and [PMID:32273485] | Aslanpour S, Han S, Schuurmans C, Kurras | The Journal of neuroscience : | 2020 | 0 |
| Single-cell epigenomic analyses implicate candidate causal variants at inherited [PMID:33106633] | ["Corces M", "Shcherbina A", "Kundu S", | Nature genetics | 2020 | 0 |
| Appropriate referring. [PMID:31253886] | A J Wight | British dental journal | 2019 | 0 |
| Male contraception: where are we going and where have we been? [PMID:31537614] | ["Reynolds-Wright J", "Anderson R"] | BMJ sexual & reproductive heal | 2019 | 0 |
| Histological findings in TMJ treated with high condilectomy for internal derange [PMID:29880328] | ["Pucci R", "Vellone V", "Ramieri V", "C | Journal of cranio-maxillo-faci | 2018 | 0 |
| Activation of TRPV4 by dietary apigenin antagonizes renal fibrosis in deoxycorti [PMID:28143892] | ["Wei X", "Gao P", "Pu Y", "Li Q", "Yang | Clinical science (London, Engl | 2017 | 0 |
| Hemophilia A treatment: disruptive technology ahead. [PMID:27034415] | ["Makris M"] | Blood | 2016 | 0 |
| Novel INHAT repressor (NIR) is required for early lymphocyte development. [PMID:25201955] | ["Ma C", "Pusso A", "Wu L", "Zhao Y", "H | Proceedings of the National Ac | 2014 | 0 |
| daf-16 integrates developmental and environmental inputs to mediate aging in the [PMID:11747825] | ["Henderson S", "Johnson T"] | Current biology : CB | 2001 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning NETRIN-1 in their description or question text
No additional research found