| TDP-43 Pathology | Phosphorylated, ubiquitinated, and truncated TDP-43 inclusions |
| Limbic Predominance | Primary involvement of amygdala, hippocampus, and entorhinal cortex |
| Age Association | Typically onset after age 80 |
| Clinical Phenotype | Amnestic syndrome resembling AD but with distinct progression |
| Age 70-79 | Approximately 5-10% prevalence |
| Age 80-89 | Approximately 15-20% prevalence |
| Age 90+ | Up to 25-30% prevalence in some cohorts |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
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