gene 1,479 words KG: IDO1
Contents

IDO1 — Indoleamine 2,3-Dioxygenase 1

🧬 Gene Info
Gene SymbolIDO1
Full NameIndoleamine 2,3-Dioxygenase 1
Chromosome8p11.21
Functionis a gene on chromosome 8p11.
Primary ExpressionMicroglia, astrocytes, macrophages, dendritic cells
Molecular Weight45 kDa
Amino Acids403 aa
Exons10
PathwaysGlycolysis, blood-brain barrier, ferroptosis, oxidative stress response, synaptic plasticity
UniProt IDP14902
NCBI Gene ID3620
Ensembl IDENSG00000131203
OMIM147435
GeneCardsIDO1
Human Protein AtlasIDO1
Associated Diseasescancer, Infection, neuroinflammation
InteractionsAHR, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, ASTROCYTE, CANCER
KG Connections87 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (3)

Selective TLR4 Modulation to Prevent Gut-Derived Neuroinflam
Score: 0.79
Restoring Neuroprotective Tryptophan Metabolism via Targeted
Score: 0.61
Microbiome-Derived Tryptophan Metabolite Neuroprotection
Score: 0.43

Related Analyses (3)

How does engineered C. butyricum cross the blood-brain barri
neurodegeneration · completed
What are the mechanisms by which gut microbiome dysbiosis in
neurodegeneration · completed
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (12)

Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40
Neural Oscillation Dysfunction Validation in Parkinson's Dis
clinical · proposed · Score: 0.40

See Also (8)

Amyloid-Related Imaging Abnormalities (ARIA)
entity · KG edge: activates
astrocyte-neuron-metabolic-coupling-parkinsons
general · KG edge: inhibits
Ferroptosis Validation in Parkinson's Disease
experiment · KG edge: expressed_in
Genes
index · KG edge: activates
CCL5 — C-C Motif Chemokine Ligand 5
gene · KG edge: activates

Knowledge Graph (12 edges)

IDO1 catalyzes tryptophan
IDO1 produces kynurenine
SLC7A11 expressed_in IDO1
IDO1 expressed_in SLC7A11
TPH2 activates IDO1
IDO1 activates GBA
SRC inhibits IDO1
PI3K inhibits IDO1
STAT3 activates IDO1
CCL5 activates IDO1

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