gene

HCRTR1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HCRTR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

333Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

1Debates

Summary

HCRTR1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, activates, therapeutic target. Associated with ALS, Als, Cardiovascular. Connected to 56 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	HCRT1
Full Name	HCRTR1
Protein Type	Gpcr
Target Class	Gpcr
Function	Small molecule antagonist blocking orexin receptor signaling
Mechanism of Action	Small molecule antagonist blocking orexin receptor signaling
Druggability	Medium (0.60)
Clinical Stage	Approved
Amino Acids	33 aa
Pathways	Circadian rhythm / glymphatic clearance, NF-κB signaling, Sleep-Wake Transition
UniProt ID	A6NMV7
GeneCards	HCRT1
Human Protein Atlas	HCRT1
Orexin-A (Hypocretin-1)	A 33-amino acid peptide with two disulfide bonds[@sakurai2007]
Orexin-B (Hypocretin-2)	A 28-amino acid linear peptide[@sakurai2007]
Associated Diseases	Addiction, Als, Alzheimer, Alzheimer's disease
Known Drugs/Compounds	Propofol
Interactions	5-HT1AR, ACE, ADRA1A, ADRA1B, AND, AQP4
SciDEX Target	View Target Profile (8 clinical trials)
KG Connections	330 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: HCRTR1 — AlphaFold A6NMV7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HCRTR1

gene · 765 words

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Pathway Diagram

graph TD
    HCRTR1["HCRTR1"]
    Sleep_Wake_Transition(["Sleep-Wake Transition"])
    HCRTR1 -->|"associated with"| Sleep_Wake_Transition
    Hemodynamic_Stability["Hemodynamic Stability"]
    HCRTR1 -->|"associated with"| Hemodynamic_Stability
    Propofol["Propofol"]
    HCRTR1 -->|"interacts with"| Propofol
    neurodegeneration{"neurodegeneration"}
    HCRTR1 -->|"associated with"| neurodegeneration
    HCRTR2["HCRTR2"]
    HCRTR1 -->|"interacts with"| HCRTR2
    Als{"Als"}
    HCRTR1 -->|"associated with"| Als
    Obesity{"Obesity"}
    HCRTR1 -->|"therapeutic target"| Obesity
    Ms{"Ms"}
    HCRTR1 -->|"associated with"| Ms
    Diabetes{"Diabetes"}
    HCRTR1 -->|"associated with"| Diabetes
    Cardiovascular{"Cardiovascular"}
    HCRTR1 -->|"associated with"| Cardiovascular
    HCRTR1 -->|"activates"| Ms
    HCRTR1 -->|"activates"| Als
    h_9e9fee95["h-9e9fee95"]
    h_9e9fee95 -->|"therapeutic target"| HCRTR1
    h_9e9fee95 -->|"targets"| HCRTR1
    HCRTR2 -->|"interacts with"| HCRTR1
    HCRTR2 -->|"regulates"| HCRTR1
    HCRTR2 -->|"therapeutic target"| HCRTR1
    PNOC["PNOC"]
    PNOC -->|"therapeutic target"| HCRTR1
    TRPC6["TRPC6"]
    TRPC6 -->|"therapeutic target"| HCRTR1
    HCRTR2 -->|"associated with"| HCRTR1
    DRD2["DRD2"]
    DRD2 -->|"activates"| HCRTR1
    HRH3["HRH3"]
    HRH3 -->|"activates"| HCRTR1
    HCRTR2 -->|"activates"| HCRTR1
    ADRA1B["ADRA1B"]
    ADRA1B -->|"activates"| HCRTR1
    style HCRTR1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (226)

Target	Relation	Type	Str
HCRTR2	associated_with	gene	0.90
Overall Survival	biomarker_for	phenotype	0.90
Relapse Free Survival	biomarker_for	phenotype	0.90
BDNF	inhibits	protein	0.85
alcohol drinking	regulates	phenotype	0.85
cognitive dysfunction	promotes	phenotype	0.85
CRF	interacts_with	protein	0.85
Sleep-Wake Transition	regulates	process	0.85
Sleep-Wake Transition	associated_with	process	0.85
Interindividual Variability In Anesthetic Response	contributes_to	phenotype	0.82
Time To Wake	associated_with	phenotype	0.80
Narcolepsy	implicated_in	disease	0.80
Time To Loss Of Consciousness	associated_with	phenotype	0.80
BNST neuronal excitability	regulates	phenotype	0.80
therapeutic_target	therapeutic_target	process	0.80
Loss Of Consciousness	associated_with	phenotype	0.80
lactate production	inhibits	process	0.80
Hemodynamic Stability	associated_with	phenotype	0.80
orexin_receptor_1	encodes	protein	0.80
hemodynamic stability	regulates	phenotype	0.75
autonomic function	regulates	process	0.75
Breast Carcinoma	therapeutic_target	disease	0.75
Propofol	interacts_with	drug	0.75
sleep-wake transition	associated_with	biological_process	0.70
HCRTR2	interacts_with	gene	0.70
neurodegeneration	associated_with	disease	0.70
Cancer	expressed_in	disease	0.65
Als	inhibits	disease	0.65
Alzheimer	regulates	disease	0.65
Glioblastoma	expressed_in	disease	0.65
Depression	associated_with	disease	0.65
Dementia	regulates	disease	0.65
Als	regulates	disease	0.65
ALS	associated_with	disease	0.65
Als	activates	disease	0.65
Obesity	associated_with	disease	0.65
Cardiovascular	associated_with	disease	0.65
Sleep Disorder	regulates	disease	0.65
Ms	activates	disease	0.65
ALS	activates	disease	0.65
Schizophrenia	associated_with	disease	0.65
Als	associated_with	disease	0.65
Obesity	therapeutic_target	disease	0.65
Addiction	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Ptsd	interacts_with	disease	0.65
Addiction	activates	disease	0.65
Sleep Disorder	therapeutic_target	disease	0.65
Diabetes	associated_with	disease	0.65
Depression	regulates	disease	0.65

Incoming (107)

Source	Relation	Type	Str
Orexinergic Neurons	expressed_in	cell_type	0.92
HCRT	associated_with	gene	0.90
NEURON	interacts_with	cell_type	0.90
h-9e9fee95	targets	hypothesis	0.90
HCRTR2	interacts_with	gene	0.70
CD4	expressed_in	gene	0.60
BDNF	inhibits	gene	0.60
HCRT2	associated_with	gene	0.60
PNOC	therapeutic_target	gene	0.60
HCRTR2	therapeutic_target	gene	0.60
ACE	interacts_with	gene	0.60
HCRTR2	associated_with	gene	0.60
LRRTM2	biomarker_for	gene	0.60
HRH3	activates	gene	0.60
DEPRESSION	associated_with	gene	0.60
GRIA1	activates	gene	0.60
DRD1	activates	gene	0.60
HCRTR2	regulates	gene	0.60
ADRA1A	activates	gene	0.60
HRH1	activates	gene	0.60
GRIN1	activates	gene	0.60
BDNF	activates	entity	0.60
BRCA	expressed_in	gene	0.60
CPLX3	activates	gene	0.60
HCRTR2	expressed_in	gene	0.60
HCRT	interacts_with	gene	0.60
DRD2	activates	gene	0.60
PNOC	associated_with	gene	0.60
HCRT	regulates	gene	0.60
GBM	inhibits	gene	0.60
ADRA1B	activates	gene	0.60
CPLX3	inhibits	gene	0.60
LRRTM2	expressed_in	gene	0.60
HCRT	activates	gene	0.60
ACE	associated_with	gene	0.60
CHRM4	expressed_in	gene	0.60
MYO7A	activates	gene	0.60
GRM2	expressed_in	gene	0.60
WNT1	activates	gene	0.60
CRH	expressed_in	gene	0.60
ADRA2B	expressed_in	gene	0.60
IL13	activates	gene	0.60
CHRNE	expressed_in	gene	0.60
WNT11	activates	gene	0.60
GRIN3B	expressed_in	gene	0.60
TNFRSF1B	activates	gene	0.60
HCRTR2	activates	gene	0.60
TNFRSF13C	activates	gene	0.60
TRPC6	therapeutic_target	gene	0.60
BDNF	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Perivascular spaces and glymphatic clearance failure in AD

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.841

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Perivascular spaces and glymphatic clearance failure in AD

closed · Rounds: 4 · Score: 0.95 · 2026-04-06

Related Research

Hypotheses and analyses mentioning HCRTR1 in their description or question text

No additional research found