protein

FAN1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FAN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections

0Hypotheses

0Analyses

12Outgoing

3Incoming

0Experiments

0Debates

Summary

FAN1 is a protein involved in neurodegeneration research. Key relationships include: associated with, implicated in. Associated with Als, Huntington, Ms. Connected to 10 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	FAN1
Full Name	FANCD2 Associated Nuclease 1
Chromosome	15q13.1-q13.3
Function	is a DNA repair nuclease that plays a critical role in interstrand crosslink repair
Primary Expression	peripheral tissues
Molecular Weight	86 kDa
UniProt ID	Q8IY92 (FAN1)
NCBI Gene ID	22919
Ensembl ID	ENSG00000101391
OMIM	613375
GeneCards	FAN1
Human Protein Atlas	FAN1
Associated Diseases	Als, Huntington, Ms
Interactions	DNA, HTT, MSH3, PMS2
KG Connections	15 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FAN1 — AlphaFold Q8IY92 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

FAN1 Gene

gene · 699 words

→

FAN1 Protein

protein · 793 words

→

Pathway Diagram

graph TD
    FAN1["FAN1"]
    Huntington{"Huntington"}
    FAN1 -->|"associated with"| Huntington
    Als{"Als"}
    FAN1 -->|"associated with"| Als
    Ms{"Ms"}
    FAN1 -->|"associated with"| Ms
    DNA["DNA"]
    FAN1 -->|"associated with"| DNA
    HTT["HTT"]
    FAN1 -->|"associated with"| HTT
    PMS2["PMS2"]
    FAN1 -->|"associated with"| PMS2
    HUNTINGTON["HUNTINGTON"]
    FAN1 -->|"associated with"| HUNTINGTON
    AND["AND"]
    FAN1 -->|"associated with"| AND
    neurodegeneration["neurodegeneration"]
    FAN1 -->|"implicated in"| neurodegeneration
    MSH3["MSH3"]
    MSH3 -->|"associated with"| FAN1
    GENETIC_MODIFIERS["GENETIC MODIFIERS"]
    GENETIC_MODIFIERS -->|"associated with"| FAN1
    style FAN1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (12)

Target	Relation	Type	Str
Als	associated_with	disease	0.65
Ms	associated_with	disease	0.65
Huntington	associated_with	disease	0.65
PMS2	activates	gene	0.60
DNA	associated_with	gene	0.60
HUNTINGTON	associated_with	gene	0.60
FANCI	regulates	gene	0.60
HTT	associated_with	gene	0.60
FANCD2	regulates	gene	0.60
PMS2	associated_with	gene	0.60
HTT	activates	gene	0.60
MSH3	activates	gene	0.60

Incoming (3)

Source	Relation	Type	Str
GENETIC MODIFIERS	associated_with	gene	0.60
MSH3	associated_with	gene	0.60
DNA	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning FAN1 in their description or question text

No additional research found