| Gene Symbol | FANCD2 |
| Full Name | Fanconi Anemia Group D2 |
| Chromosome | 3p25.3 |
| Function | FANCD2 is a key protein in the Fanconi anemia (FA) DNA repair pathway, which is essential for resolving DNA interstrand crosslinks (ICLs). |
| Primary Expression | most tissues, with high expression in: |
| Molecular Weight | 164 kDa |
| Amino Acids | 1451 aa |
| Pathways | Dna Damage Response, Ferroptosis, Ferroptosis Pathway, Reactive Oxygen Species, autophagy pathway |
| UniProt ID | FANCD2 |
| Ensembl ID | ENSG00000144554 |
| OMIM | 227646 |
| GeneCards | FANCD2 |
| Human Protein Atlas | FANCD2 |
| DNA Interstrand Crosslink Repair | FANCD2 monoubiquitination is required for ICL repair during S and G2 phases |
| Homologous Recombination | Facilitates HR repair of double-strand breaks |
| Associated Diseases | Carcinoma, Tumor |
| Interactions | ALOX, AND, App, ATG, CANCER, DNA |
| KG Connections | 102 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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