Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about FANCI: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | FANCI |
| Key Genes/Proteins | AIM2, APOPTOSIS, ATM, ATR, CGAS-STING, DNA |
| Related Diseases | Als |
| Related Pathways | Apoptosis, Cgas-Sting, Dna Repair, Er Stress |
graph TD
FANCI["FANCI"]
FANCI -->|"inhibits"| RAS_signaling_pathway["RAS signaling pathway"]
FANCI -->|"contributes to"| Als["Als"]
FANCI -->|"contributes to"| Senescence["Senescence"]
FANCI -->|"interacts"| P53["P53"]
FANCI -->|"interacts"| PPM1D["PPM1D"]
FANCI -->|"interacts"| FANCE["FANCE"]
FANCI -->|"contributes to"| AIM2["AIM2"]
FANCI -->|"interacts"| ATR["ATR"]
FANCC["FANCC"] -->|"interacts"| FANCI
APOPTOSIS["APOPTOSIS"] -->|"contributes to"| FANCI
ATM["ATM"] -->|"interacts"| FANCI
FANCA["FANCA"] -->|"interacts"| FANCI
DNA["DNA"] -->|"interacts"| FANCI
CGAS_STING["CGAS-STING"] -->|"contributes to"| FANCI| Target | Relation | Type | Str |
|---|---|---|---|
| RAS signaling pathway | inhibits | pathway | 0.85 |
| Als | contributes_to | disease | 0.65 |
| Senescence | contributes_to | disease | 0.65 |
| FANCE | interacts_with | gene | 0.60 |
| AIM2 | contributes_to | gene | 0.60 |
| ATR | interacts_with | gene | 0.60 |
| Inflammasome | contributes_to | pathway | 0.60 |
| Er Stress | contributes_to | pathway | 0.60 |
| Apoptosis | contributes_to | pathway | 0.60 |
| P53 | interacts_with | gene | 0.60 |
| Neuron | contributes_to | cell_type | 0.60 |
| PPM1D | interacts_with | gene | 0.60 |
| ATM | interacts_with | gene | 0.60 |
| DNA | interacts_with | gene | 0.60 |
| FANCC | interacts_with | gene | 0.60 |
| APOPTOSIS | contributes_to | gene | 0.60 |
| FANCA | interacts_with | gene | 0.60 |
| CGAS-STING | contributes_to | gene | 0.60 |
| Dna Repair | interacts_with | pathway | 0.60 |
| Cgas-Sting | contributes_to | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning FANCI in their description or question text
No additional research found