gene

ELAVL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ELAVL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

109Connections

0Hypotheses

0Analyses

50Outgoing

23Incoming

0Experiments

0Debates

Summary

ELAVL1 (HuR) RNA-binding protein involved in mRNA stability, synaptic plasticity, and neurodegenerative disease mechanisms

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🧬 Gene Info

Gene Symbol	ELAVL1
Chromosome	19p13.2
Protein Type	Gene
Function	is a member of the ELAV (Embryonic Lethal Abnormal Vision) family of RNA-binding proteins.
Primary Expression	neurons throughout the central and peripheral nervous systems:
Subcellular Localization	and RNA binding activity[@lee2020]
Molecular Weight	36 kDa
Amino Acids	326 aa
Exons	10
Pathways	Autophagy, Ferroptosis, Proteasome, Ubiquitin-Proteasome
GeneCards	ELAVL1
Human Protein Atlas	ELAVL1
Phosphorylation	By multiple kinases including Chk2, PKC, and CDK1, affecting its subcellular localization and RNA binding activity[@lee2020]
Methylation	Arginine methylation by PRMT1 modulates RNA binding affinity
Acetylation	Lysine acetylation influences protein-protein interactions
Associated Diseases	Carcinoma, Hepatocellular Carcinoma, Tumor
Interactions	ACTB, AND, ATF3, ATG, AUTOPHAGY, BECLIN1
KG Connections	108 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ELAVL1 Gene

gene · 1559 words

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Pathway Diagram

graph TD
    ELAVL1["ELAVL1"]
    Cancer{"Cancer"}
    ELAVL1 -->|"activates"| Cancer
    Carcinoma{"Carcinoma"}
    ELAVL1 -->|"activates"| Carcinoma
    ELAVL1 -->|"associated with"| Carcinoma
    Tumor{"Tumor"}
    ELAVL1 -->|"associated with"| Tumor
    Ms{"Ms"}
    ELAVL1 -->|"interacts with"| Ms
    Fibrosis{"Fibrosis"}
    ELAVL1 -->|"activates"| Fibrosis
    ELAVL1 -->|"therapeutic target"| Fibrosis
    Als{"Als"}
    ELAVL1 -->|"activates"| Als
    ELAVL1 -->|"therapeutic target"| Ms
    GPX4["GPX4"]
    ELAVL1 -->|"associated with"| GPX4
    ATG["ATG"]
    ELAVL1 -->|"associated with"| ATG
    FN1["FN1"]
    ELAVL1 -->|"associated with"| FN1
    NSUN2["NSUN2"]
    NSUN2 -->|"activates"| ELAVL1
    YBX1["YBX1"]
    YBX1 -->|"interacts with"| ELAVL1
    SQSTM1["SQSTM1"]
    SQSTM1 -->|"associated with"| ELAVL1
    TNF["TNF"]
    TNF -->|"associated with"| ELAVL1
    ATF3["ATF3"]
    ATF3 -->|"activates"| ELAVL1
    GOT1["GOT1"]
    GOT1 -->|"associated with"| ELAVL1
    GPT["GPT"]
    GPT -->|"associated with"| ELAVL1
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"activates"| ELAVL1
    TP53["TP53"]
    TP53 -->|"associated with"| ELAVL1
    NCOA4["NCOA4"]
    NCOA4 -->|"associated with"| ELAVL1
    UBIQUITIN["UBIQUITIN"]
    UBIQUITIN -->|"interacts with"| ELAVL1
    AND["AND"]
    AND -->|"activates"| ELAVL1
    style ELAVL1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (86)

Target	Relation	Type	Str
mRNA	associated_with	compound	0.90
mRNA Stability	mediates	process	0.85
Carcinoma	associated_with	disease	0.75
Hepatocellular Carcinoma	associated_with	disease	0.75
ATG	associated_with	gene	0.70
Autophagy	activates	pathway	0.70
PTGS2	associated_with	gene	0.70
NCOA4	associated_with	gene	0.70
P62	associated_with	gene	0.70
FTH1	associated_with	gene	0.70
COL1A1	associated_with	gene	0.70
ROS	associated_with	gene	0.70
SQSTM1	associated_with	gene	0.70
Fibrosis	activates	disease	0.65
Cancer	activates	disease	0.65
Carcinoma	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Tumor	associated_with	disease	0.65
Ms	interacts_with	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Als	activates	disease	0.65
MAPK signaling	participates_in	pathway	0.60
RNA	regulates	gene	0.60
ROS	interacts_with	gene	0.60
traumatic brain injury	interacts_with	disease	0.60
NSUN2	activates	gene	0.60
YBX1	interacts_with	gene	0.60
ATF3	activates	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
TNF	associated_with	gene	0.60
FN1	associated_with	gene	0.60
ZFP36	associated_with	gene	0.60
FBXW7	associated_with	gene	0.60
P53	associated_with	gene	0.60
Autophagy	associated_with	pathway	0.60
Ferroptosis	interacts_with	pathway	0.60
Proteasome	activates	pathway	0.60
Ferroptosis	activates	pathway	0.60
AND	activates	gene	0.60
Ubiquitin-Proteasome	activates	pathway	0.60
HDGF	activates	gene	0.60
RNA	interacts_with	gene	0.60
G6PD	expressed_in	gene	0.60
MAP	expressed_in	gene	0.60
MAPK	expressed_in	gene	0.60
MRPS31	expressed_in	gene	0.60
necroptosis	participates_in	pathway	0.60
FERROPTOSIS	activates	gene	0.60
YBX1	therapeutic_target	entity	0.60
AUTOPHAGY	associated_with	gene	0.60

Incoming (23)

Source	Relation	Type	Str
GPX4	associated_with	gene	0.70
ATG	interacts_with	gene	0.60
COL1A1	interacts_with	gene	0.60
SQSTM1	associated_with	gene	0.60
TNF	associated_with	gene	0.60
AUTOPHAGY	activates	gene	0.60
HDGF	activates	gene	0.60
RNA	interacts_with	gene	0.60
ATF3	activates	gene	0.60
GOT1	associated_with	gene	0.60
GPT	associated_with	gene	0.60
BECN1	activates	gene	0.60
ACTB	interacts_with	gene	0.60
BECN1	interacts_with	gene	0.60
NSUN2	activates	gene	0.60
YBX1	interacts_with	gene	0.60
ABCA7	expressed_in	gene	0.60
ARF1	expressed_in	gene	0.60
ATG7	expressed_in	gene	0.60
E2F2	expressed_in	gene	0.60
TP53	associated_with	gene	0.60
NCOA4	associated_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning ELAVL1 in their description or question text

No additional research found