protein 1,729 words KG: DAOPROTEIN
Contents

DAO Protein (D-Amino Acid Oxidase)

🔬 Protein Info
Gene SymbolDAO
Full NameD-Amino Acid Oxidase
Chromosome12q24.11
Protein TypeEnzyme
Functionencodes a flavin adenine dinucleotide (FAD)-dependent enzyme that catalyzes the oxidative deamination of D-amino acids.
Primary ExpressionBrain (neurons, astrocytes), liver, kidney
Molecular Weight39 kDa
Amino Acids347 aa
UniProt IDP14920
NCBI Gene ID1680
Ensembl IDENSG00000110888
OMIM124050
GeneCardsDAO
Human Protein AtlasDAO
D-SerineThe most important physiological substrate in the brain
Associated DiseasesAls, Bipolar, Depression, Ms, Schizophrenia
InteractionsDISC1, G72, GRIN2B, GRM3, GRM4, NCAM1
KG Connections90 knowledge graph edges
DatabasesGeneCardsHPASTRING

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UniProtWikipedia

Related Hypotheses (5)

Selective Acid Sphingomyelinase Modulation Therapy
Score: 0.75
Matrix Stiffness Normalization via Targeted Lysyl Oxidase In
Score: 0.71
Heat Shock Protein 70 Disaggregase Amplification
Score: 0.62
Serine/Arginine-Rich Protein Kinase Modulation
Score: 0.62
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.62

Related Analyses (8)

Lipid raft composition changes in synaptic neurodegeneration
neurodegeneration · completed
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Perivascular spaces and glymphatic clearance failure in AD
neurodegeneration · archived
TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (13)

PS-NMP shape-dependent colonic barrier damage in mice
validation · proposed · Score: 0.95
Animal Model Comparison for Neurodegenerative Disease Therap
clinical · proposed · Score: 0.40
Endocannabinoid System Dysfunction Validation in Parkinson's
clinical · proposed · Score: 0.40
Glymphatic-Circadian Axis Enhancement Therapy for Parkinson'
clinical · proposed · Score: 0.40
Gut Microbiome-Derived Metabolites in Alpha-Synuclein Propag
clinical · proposed · Score: 0.40

See Also (1)

Neurodegeneration
disease · KG edge: implicated_in

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