gene

SPG11

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SPG11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

30Connections

0Hypotheses

0Analyses

12Outgoing

18Incoming

0Experiments

0Debates

Summary

SPG11 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in, inhibits. Associated with Inflammation, Neurodegeneration, Neuroinflammation. Connected to 13 entities in the SciDEX knowledge graph.

View on Wiki →

No AI portrait yet

🧬 Gene Info

Gene Symbol	SPG11
Aliases	Page for SPG11 Gene
Chromosome	10p14
Function	is a large cytoplasmic protein encoded by the SPG11 gene located on chromosome 15q21.
Primary Expression	Predominantly neuronal
Molecular Weight	250 kDa
Amino Acids	163 aa
Exons	40
UniProt ID	Q96MC7
NCBI Gene ID	80208
GeneCards	SPG11
Human Protein Atlas	SPG11
Central nervous system	Cerebral cortex, hippocampus, basal ganglia, thalamus, cerebellum
Spinal cord	Motor neurons, interneurons
Peripheral nervous system	Dorsal root ganglia
Associated Diseases	Inflammation, neurodegeneration, Neuroinflammation
Interactions	MICROGLIA, NEURODEGENERATION
KG Connections	30 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: SPG11 — AlphaFold Q96MC7 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    SPG11["SPG11"]
    Neuroinflammation{"Neuroinflammation"}
    SPG11 -->|"associated with"| Neuroinflammation
    Neurodegeneration{"Neurodegeneration"}
    SPG11 -->|"inhibits"| Neurodegeneration
    Inflammation{"Inflammation"}
    SPG11 -->|"associated with"| Inflammation
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    SPG11 -->|"associated with"| NEUROINFLAMMATION
    Innate_Immunity(["Innate Immunity"])
    SPG11 -->|"associated with"| Innate_Immunity
    neurodegeneration["neurodegeneration"]
    SPG11 -->|"implicated in"| neurodegeneration
    MICROGLIA["MICROGLIA"]
    MICROGLIA -->|"activates"| SPG11
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"associated with"| SPG11
    NEURODEGENERATION["NEURODEGENERATION"]
    NEURODEGENERATION -->|"inhibits"| SPG11
    style SPG11 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (12)

Target	Relation	Type	Str
Neuroinflammation	associated_with	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Inflammation	associated_with	disease	0.65
NEUROINFLAMMATION	associated_with	gene	0.60
Innate Immunity	associated_with	pathway	0.60
Autophagy	implicated_in	pathway	0.60
TAF15	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
VAPB	associated_with	gene	0.60
VCP	associated_with	gene	0.60
neurodegeneration	associated_with	disease	0.60
SPG15	associated_with	gene	0.60

Incoming (18)

Source	Relation	Type	Str
MICROGLIA	activates	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
LYSOSOME	implicated_in	gene	0.60
AUTOPHAGY	implicated_in	gene	0.60
ALS	associated_with	gene	0.60
ALS2	associated_with	gene	0.60
ANG	associated_with	gene	0.60
DAO	associated_with	gene	0.60
DCTN1	associated_with	gene	0.60
FIG4	associated_with	gene	0.60
FUS	associated_with	gene	0.60
NEFH	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
SETX	associated_with	gene	0.60
GBA1	associated_with	gene	0.60
SMPD1	associated_with	gene	0.60
SNCA	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning SPG11 in their description or question text

No additional research found