concept

PI3K/AKT/MTOR PATHWAY

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about PI3K/AKT/MTOR PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

88Connections

0Hypotheses

0Analyses

50Outgoing

29Incoming

0Experiments

0Debates

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💡 Concept Info

Name	PI3K/AKT/MTOR PATHWAY

Pathway Diagram

graph TD
    PI3K_AKT_MTOR_PATHWAY["PI3K/AKT/MTOR PATHWAY"]
    PI3K_AKT_MTOR_PATHWAY -->|"involved_in"| Cancer["Cancer"]
    PI3K_AKT_MTOR_PATHWAY -->|"contributes to"| Hormone_Receptor_Positive_Adva["Hormone Receptor-Positive Advanced Breast Cancer"]
    PI3K_AKT_MTOR_PATHWAY -->|"involved_in"| Breast_Cancer["Breast Cancer"]
    PI3K_AKT_MTOR_PATHWAY -->|"promotes"| Tumor_Growth["Tumor Growth"]
    PI3K_AKT_MTOR_PATHWAY -->|"mediates"| Endocrine_Therapy_Resistance["Endocrine Therapy Resistance"]
    PI3K_AKT_MTOR_PATHWAY -->|"mediates"| Cdk4_6_Inhibitor_Resistance["Cdk4/6 Inhibitor Resistance"]
    PI3K_AKT_MTOR_PATHWAY -->|"promotes"| cell_survival["cell survival"]
    PI3K_AKT_MTOR_PATHWAY -->|"promotes"| dystrophic_neurites["dystrophic neurites"]
    Piperine["Piperine"] -->|"activates"| PI3K_AKT_MTOR_PATHWAY
    PIK3CA["PIK3CA"] -->|"involved_in"| PI3K_AKT_MTOR_PATHWAY
    CHRYSOTOXINE["CHRYSOTOXINE"] -->|"inhibits"| PI3K_AKT_MTOR_PATHWAY
    Capivasertib["Capivasertib"] -->|"inhibits"| PI3K_AKT_MTOR_PATHWAY
    Alpelisib["Alpelisib"] -->|"inhibits"| PI3K_AKT_MTOR_PATHWAY
    MARCKS["MARCKS"] -->|"activates"| PI3K_AKT_MTOR_PATHWAY
    insulin_resistance["insulin resistance"] -->|"inhibits"| PI3K_AKT_MTOR_PATHWAY
    STX11["STX11"] -->|"inhibits"| PI3K_AKT_MTOR_PATHWAY

Outgoing (59)

Target	Relation	Type	Str
insulin resistance	regulates	process	0.95
Breast Tumorigenesis	involved_in	process	0.95
Colorectal Cancer Initiation	involved_in	process	0.95
Tumor Growth	promotes	process	0.95
Colorectal Cancer Progression	involved_in	process	0.95
Hormone Receptor-Positive Advanced Breast Cancer	contributes_to	disease	0.95
Cancer	involved_in	disease	0.95
Colorectal Cancer Metastasis	promotes	process	0.95
Breast Cancer	involved_in	disease	0.95
Insulin Resistance	regulates	phenotype	0.95
Cdk4/6 Inhibitor Resistance	mediates	mechanism	0.93
Endocrine Therapy Resistance	mediates	mechanism	0.93
cell survival	promotes	process	0.92
dystrophic neurites	promotes	phenotype	0.92
Colorectal cancer	implicated_in	disease	0.90
Cancer Progression	regulates	disease	0.90
Triple-negative breast cancer	implicated_in	disease	0.90
axonal pathology	therapeutic_target	phenotype	0.90
Endocrine Resistance	mediates	mechanism	0.90
Autophagy	mediates	process	0.90
Drug Resistance	mediates	phenotype	0.90
insulin resistance	causes	phenotype	0.90
lipid transport	regulates	process	0.90
cytoskeleton dynamics	regulates	process	0.90
macrophage activation	regulates	phenotype	0.90
protein turnover	regulates	process	0.90
Tumor Growth	involved_in	process	0.90
Gene Transcription	regulates	process	0.90
Transcriptional Targets	regulates	process	0.90
Breast cancer	implicated_in	disease	0.90
Autophagy	mediates	process	0.90
Poor Prognosis	associated_with	phenotype	0.90
Pancreatic Ductal Adenocarcinoma	involved_in	disease	0.90
Cancer Hallmarks	regulates	process	0.85
Cytoskeleton Dynamics	regulates	process	0.85
Lipid Transport	regulates	process	0.85
Hormone-Receptor-Positive Breast Cancer	contributes_to	disease	0.85
Protein Turnover	regulates	process	0.85
Cellular Growth	modulates	process	0.85
Cell Proliferation	regulates	process	0.85
Bladder Cancer	drives	disease	0.85
Apoptosis	regulates	process	0.85
Autophagy	regulates	process	0.85
Sjogren's Syndrome	involved_in	disease	0.85
Tumor Invasion	involved_in	process	0.85
Idiopathic Pulmonary Fibrosis	involved_in	disease	0.85
Tumor Metastasis	associated_with	process	0.83
Cell Death	modulates	process	0.80
TUMOR	regulates	disease	0.80
Salivary Gland Damage	involved_in	phenotype	0.80

Incoming (29)

Source	Relation	Type	Str
Piperine	activates	compound	0.95
PI3K Pathway Inhibitors	inhibits	drug	0.95
Polyphenols	targets	compound	0.95
Apigenin	inhibits	compound	0.95
PIK3CA	associated_with	gene	0.95
Glioblastoma Multiforme	associated_with	disease	0.95
Capivasertib	inhibits	drug	0.92
Alpelisib	inhibits	drug	0.92
Mtor Inhibitors	inhibits	drug	0.90
Berberine	inhibits	compound	0.90
Pi3K Inhibitors	inhibits	drug	0.90
PTEN	regulates	gene	0.90
Akt Inhibitors	inhibits	drug	0.90
Fibroblast Autophagy	inhibits	process	0.90
insulin resistance	inhibits	phenotype	0.90
STX11	inhibits	gene	0.90
PTEN	inhibits	protein	0.90
SPP1	activates	protein	0.90
Piperine	activates	compound	0.90
Sijunzi Decoction	targets	drug	0.90
PTEN	inhibits	gene	0.90
MARCKS	activates	protein	0.90
MTOR	involved_in	gene	0.88
AKT1	involved_in	gene	0.88
IRGM1	activates	protein	0.85
KRAS	activates	gene	0.85
NOBILETIN	inhibits	compound	0.80
RAF/MEK/ERK Pathway	interacts_with	pathway	0.75
Gomisin N	activates	compound	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning PI3K/AKT/MTOR PATHWAY in their description or question text

No additional research found