Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CCR6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CCR6 is a gene implicated in neurodegeneration research. Key relationships include: activates, expressed in, implicated in. Associated with ALS, Als. Connected to 11 entities in the SciDEX knowledge graph.
No AI portrait yet
| Gene Symbol | CCR6 |
| Chromosome | 6q27 |
| Protein Type | Receptor |
| Function | encodes a G protein-coupled receptor for CCL20 (MIP-3α/MIP-3a), also known as exodus-1 or LARC (Liver and Activation-Regulated Chemokine). |
| Primary Expression | rheumatoid synovium |
| Amino Acids | 374 aa |
| Exons | 4 |
| Ensembl ID | ENSG00000112486 |
| GeneCards | CCR6 |
| Human Protein Atlas | CCR6 |
| N-terminal extracellular domain | Ligand binding |
| Seven transmembrane domains | GPCR core |
| Three extracellular loops | Ligand interaction |
| Three intracellular loops | Signal transduction |
| C-terminal intracellular tail | G protein coupling and desensitization |
| Associated Diseases | neurodegeneration |
| Interactions | AND, APOE, CANCER, CCL20, CD163, CD4 |
| KG Connections | 30 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CCR6["CCR6"]
Als{"Als"}
CCR6 -->|"expressed in"| Als
ALS{"ALS"}
CCR6 -->|"expressed in"| ALS
CD163["CD163"]
CCR6 -->|"activates"| CD163
AND["AND"]
CCR6 -->|"expressed in"| AND
B_Cell["B Cell"]
CCR6 -->|"expressed in"| B_Cell
neurodegeneration["neurodegeneration"]
CCR6 -->|"implicated in"| neurodegeneration
CD4["CD4"]
CD4 -->|"activates"| CCR6
LDLR["LDLR"]
LDLR -->|"activates"| CCR6
FOXP3["FOXP3"]
FOXP3 -->|"activates"| CCR6
CD8["CD8"]
CD8 -->|"activates"| CCR6
APOE["APOE"]
APOE -->|"activates"| CCR6
GZMA["GZMA"]
GZMA -->|"activates"| CCR6
style CCR6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Memory B Cell Precursor | biomarker_for | cell_type | 0.95 |
| Germinal Center Light Zone | expressed_in | cell_type | 0.90 |
| Memory B Cell Phenotype | regulates | phenotype | 0.85 |
| Memory B Cell Differentiation | mediates | process | 0.85 |
| Quiescent State | promotes | phenotype | 0.75 |
| Als | expressed_in | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Aging | activates | disease | 0.65 |
| ALS | expressed_in | disease | 0.65 |
| FUS | activates | gene | 0.60 |
| IL6 | activates | gene | 0.60 |
| ERK1 | activates | gene | 0.60 |
| CD163 | activates | gene | 0.60 |
| APOE | activates | gene | 0.60 |
| Chemokine | associated_with | protein | 0.60 |
| B Cell | expressed_in | cell_type | 0.55 |
| B CELLS | expressed_in | concept | 0.50 |
| GENE EXPRESSION | expressed_in | concept | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning CCR6 in their description or question text
No additional research found